Dietary fibre in gastrointestinal health and disease.

Nature Reviews. Gastroenterology & Hepatology
Samantha K GillKevin Whelan

Abstract

Epidemiological studies have consistently demonstrated the benefits of dietary fibre on gastrointestinal health through consumption of unrefined whole foods, such as wholegrains, legumes, vegetables and fruits. Mechanistic studies and clinical trials on isolated and extracted fibres have demonstrated promising regulatory effects on the gut (for example, digestion and absorption, transit time, stool formation) and microbial effects (changes in gut microbiota composition and fermentation metabolites) that have important implications for gastrointestinal disorders. In this Review, we detail the major physicochemical properties and functional characteristics of dietary fibres, the importance of dietary fibres and current evidence for their use in the management of gastrointestinal disorders. It is now well-established that the physicochemical properties of different dietary fibres (such as solubility, viscosity and fermentability) vary greatly depending on their origin and processing and are important determinants of their functional characteristics and clinical utility. Although progress in understanding these relationships has uncovered potential therapeutic opportunities for dietary fibres, many clinical questions remain unanswe...Continue Reading

References

May 1, 1976·Lancet·H TrowellD J Jenkins
May 1, 1979·Journal of Clinical Pharmacology·G A SpillerW C Cooper
Sep 1, 1979·The American Journal of Clinical Nutrition·H KasperF Fehle
Jan 1, 1978·Gut·A J Brodribb, C Groves
Jun 11, 1991·The American Journal of Clinical Nutrition·E C TitgemeyerK A Garleb
Nov 5, 1988·BMJ : British Medical Journal·J Tomlin, N W Read
Feb 1, 1988·Gastroenterology·H C MitchisonO F James
Jun 9, 1973·Lancet·R F HarveyK W Heaton
Jan 1, 1981·The British Journal of Nutrition·J S GearJ I Mann
Aug 1, 1983·The Journal of Nutrition·K L WrickL R Hackler
Feb 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·W R TreemJ S Hyams
Sep 23, 1997·Scandinavian Journal of Gastroenterology·S J Lewis, K W Heaton
Feb 12, 1998·The American Journal of Clinical Nutrition·N WashingtonR C Spiller
Jul 8, 1999·The Journal of Nutrition·J O HunterA J Lee
Nov 26, 1999·The Journal of Nutrition·J RiedlG Wolfram
Dec 2, 2000·The American Journal of Clinical Nutrition·M Olesen, E Gudmand-Hoyer
May 22, 2003·The Proceedings of the Nutrition Society·Iain A BrownleeJeffrey P Pearson
Aug 9, 2003·The American Journal of Gastroenterology·Laurent DukasEdward L Giovannucci
Aug 22, 1953·British Medical Journal·E H HIPSLEY
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·Tapan K Basu, David Donaldson
May 26, 2004·The American Journal of Clinical Nutrition·Jane G MuirFinlay A Macrae
Nov 10, 2006·Critical Reviews in Food Science and Nutrition·Cheryl L Dikeman, George C Fahey
Feb 3, 2007·European Journal of Clinical Nutrition·S KolidaG R Gibson
Sep 28, 2007·International Journal of Medical Microbiology : IJMM·Hiromasa TakaishiToshifumi Hibi
Dec 6, 2007·European Journal of Clinical Nutrition·J H Cummings, A M Stephen

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Citations

Feb 28, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Erin R ShanahanHeidi M Staudacher
Mar 2, 2021·Experimental Biology and Medicine·Kirsten BerdingJohn F Cryan
May 21, 2021·Critical Reviews in Food Science and Nutrition·Huiqin GuoZhuoyu Li
Apr 24, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Kevin Whelan, Nicola Jones
Jul 3, 2021·Nutrients·Belinda RuettimannJoelle Leonie Flueck
Jun 30, 2021·Molecular Medicine Reports·Sergej NadalinAlena Buretić-Tomljanović
Aug 7, 2021·Nature Reviews. Gastroenterology & Hepatology·Caroline Barranco
Aug 11, 2021·Nature Reviews. Gastroenterology & Hepatology·Paul T HeitmannS Mark Scott
Sep 11, 2021·Food & Function·Zoi KatsirmaKevin Whelan
Oct 2, 2021·Nature Reviews. Gastroenterology & Hepatology·Tiffany ToniVictoria Gershuni
Oct 10, 2021·Signal Transduction and Targeted Therapy·Junyun SheJun Yu
Nov 2, 2021·Frontiers in Microbiology·Yifan ZhongHaifeng Wang

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Methods Mentioned

BETA
size exclusion chromatography
rheometry

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