PMID: 9181465May 1, 1997Paper

Dietary fish oil enhances circulating interferon-gamma in mice during listeriosis without altering in vitro production of this cytokine

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
K L FritscheJ N Berg

Abstract

The objective of this study was to investigate the impact of feeding mice a diet rich in n-3 polyunsaturated fatty acids (PUFA) from fish oil on the interferon-gamma (IFN-gamma) response during an active infection with Listeria monocytogenes. Weanling female C3H/Hen mice were fed experimental diets containing 20% by weight one of the following fats: soybean oil, lard, or a mixture of menhaden fish oil and corn oil (17:3, w/w). After 4 weeks, mice were injected with 10(5) live L. monocytogenes, and the concentration of IFN-gamma in serum and spleen was determined 0, 2, 4, and 7 days postinfection by enzyme-linked immunosorbent assay (ELISA). Fish oil-fed mice showed significantly higher IFN-gamma in their blood at 2 and 4 days postchallenge compared with mice fed the soybean oil-containing or lard-containing diets (p < 0.001). A higher concentration of IFN-gamma was also found in the spleen homogenate of fish oil-fed mice on day 4 postchallenge (p < 0.005). To examine in vitro IFN-gamma production, splenocytes were isolated from fish oil-fed and soybean oil-fed mice on day 4 postchallenge and cultured with concanavalin A (1 microgram/ml and 10 micrograms/ml) for 24 and 48 h. There were no significant differences in the IFN-gamma...Continue Reading

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Citations

Dec 11, 2013·Periodontology 2000·Dolphus R DawsonJeffrey L Ebersole
Feb 27, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C FengK L Fritsche
Dec 19, 2000·FEMS Immunology and Medical Microbiology·M A de PabloG Alvarez de Cienfuegos

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