Dietary Fish Oil Inhibits Pro-Inflammatory and ER Stress Signalling Pathways in the Liver of Sows during Lactation

PloS One
Denise K GessnerKlaus Eder

Abstract

Lactating sows have been shown to develop typical signs of an inflammatory condition in the liver during the transition from pregnancy to lactation. Hepatic inflammation is considered critical due to the induction of an acute phase response and the activation of stress signaling pathways like the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR), both of which impair animal's health and performance. Whether ER stress-induced UPR is also activated in the liver of lactating sows and whether dietary fish oil as a source of anti-inflammatory effects n-3 PUFA is able to attenuate hepatic inflammation and ER stress-induced UPR in the liver of sows is currently unknown. Based on this, two experiments with lactating sows were performed. The first experiment revealed that ER stress-induced UPR occurs also in the liver of sows during lactation. This was evident from the up-regulation of a set of genes regulated by the UPR and numerically increased phosphorylation of the ER stress-transducer PERK and PERK-mediated phosphorylation of eIF2α and IκB. The second experiment showed that fish oil inhibits ER stress-induced UPR in the liver of lactating sows. This was demonstrated by decreased mRNA levels of a number of UP...Continue Reading

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Citations

Jul 28, 2016·Journal of Animal Physiology and Animal Nutrition·D K GessnerK Eder
Jan 19, 2018·Animal : an International Journal of Animal Bioscience·T KomprdaM Faldyna
Dec 11, 2019·Tropical Animal Health and Production·Arash VeshkiniAbdolreza Salehi
Apr 28, 2019·Animals : an Open Access Journal From MDPI·Laurentiu Mihai PaladeIonelia Taranu
Nov 7, 2019·Annual Review of Animal Biosciences·Robert RingseisKlaus Eder

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

Rotorgene
Syngene GeneTools
PRIMER3
BLAST
GeNorm

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