PMID: 9435038Jan 1, 1997Paper

Dietary fish oil supplementation increases survival in mice following Klebsiella pneumoniae infection

Scandinavian Journal of Infectious Diseases
S BjörnssonA Haraldsson

Abstract

The effect of dietary fish-oil supplementation on survival of NMRI mice after Klebsiella pneumoniae infection was investigated. 30 mice in each group were fed a fish-oil enriched diet, olive-oil enriched diet or standard chow diet. After 6 weeks, the mice were injected intramuscularly with Klebsiella pneumoniae. After 120 h the survival of the mice fed fish-oil enriched diet was 40%, while the survival for mice fed standard or olive-oil enriched diets was 20% and 25%, respectively. The survival curve over 120 h was significantly improved (p = 0.0034) for mice fed a fish-oil enriched diet, compared to the survival curves for mice fed the other 2 diets. The study was repeated by comparing the survival of mice fed a fish-oil enriched diet to those given a corn-oil enriched diet. After 120 h the survival curve for mice fed the fish-oil enriched diet was significantly better compared to the survival curve for mice given the corn-oil enriched diet (p = 0.01). A fish-oil enriched diet therefore increases survival in mice following Klebsiella pneumoniae infection, whether compared to a standard diet, olive-oil enriched diet or corn-oil enriched diet.

References

Jan 1, 1992·Metabolism: Clinical and Experimental·H R ChangJ C Pechère
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·P Clouva-MolyvdasJ W Alexander

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Citations

Dec 19, 2000·FEMS Immunology and Medical Microbiology·M A de PabloG Alvarez de Cienfuegos
Jan 21, 2000·FEMS Immunology and Medical Microbiology·M A de PabloG Alvarez de Cienfuegos
Dec 11, 2013·Periodontology 2000·Dolphus R DawsonJeffrey L Ebersole
Apr 6, 2004·Scandinavian Journal of Infectious Diseases·Valtýr Stefánsson ThorsAsgeir Haraldsson
Sep 24, 2004·Scandinavian Journal of Immunology·V S ThorsA Haraldsson
Aug 3, 2006·Journal of Applied Microbiology·G Midelet-BourdinP Malle
Jan 29, 2000·Immunology and Cell Biology·M A de Pablo, G Alvarez de Cienfuegos
Sep 3, 2002·Clinical and Diagnostic Laboratory Immunology·Manuel A de PabloGerardo Alvarez de Cienfuegos

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