Dietary flavonoid intakes and CVD incidence in the Framingham Offspring Cohort

The British Journal of Nutrition
Paul F JacquesJohanna T Dwyer

Abstract

This study examines the relationship between long-term intake of six flavonoid classes and incidence of CVD and CHD, using a comprehensive flavonoid database and repeated measures of intake, while accounting for possible confounding by components of a healthy dietary pattern. Flavonoid intakes were assessed using a FFQ among the Framingham Offspring Cohort at baseline and three times during follow-up. Cox proportional hazards regression was used to characterise prospective associations between the natural logarithms of flavonoid intakes and CVD incidence using a time-dependent approach, in which intake data were updated at each examination to represent average intakes from previous examinations. Mean baseline age was 54 years, and 45 % of the population was male. Over an average 14·9 years of follow-up among 2880 participants, there were 518 CVD events and 261 CHD events. After multivariable adjustment, only flavonol intake was significantly associated with lower risk of CVD incidence (hazard ratios (HR) per 2·5-fold flavonol increase=0·86, P trend=0·05). Additional adjustment for total fruit and vegetable intake and overall diet quality attenuated this observation (HR=0·89, P trend=0·20 and HR=0·92, P trend=0·33, respectively)...Continue Reading

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Citations

May 10, 2017·Molecular Aspects of Medicine·Aedín Cassidy
Apr 7, 2017·The British Journal of Nutrition·Tomoyuki Kawada
Jun 3, 2017·Annual Review of Nutrition·Johanna T Dwyer
Jul 30, 2020·Food & Function·Benjamin H ParmenterNicola P Bondonno
Aug 5, 2016·The American Journal of Clinical Nutrition·Aedín CassidyEric B Rimm
Jul 25, 2019·Current Pharmaceutical Design·Kazuo Yamagata
Sep 3, 2021·The British Journal of Nutrition·Ze-Kai FanDuo Li

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