Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma

International Journal of Cancer. Journal International Du Cancer
Kim S KraunzKarl T Kelsey

Abstract

Inactivation of the p16(INK4A) (CDKN2A) gene in the Rb pathway is among the most common somatic alterations observed in tobacco-related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16(INK4A) gene. In an ongoing population-based study of HNSCC, we sought to extend this observation to human disease testing the hypothesis that p16(INK4A) methylation is associated with decreased dietary folate. We also investigated the association of methylation silencing with functional polymorphisms in the folate metabolism enzyme methylene tetrahydrofolate reductase (MTHFR). In 169 HNSCCs, the odds ratio for p16(INK4A) methylation among those with low dietary folate intake was 2.3 (95% CI = 1.1-4.8) when compared with those with high folate intake. Furthermore, this increased risk for epigenetic silencing at p16(INK4A) was modified by the MTHFR alleles previously associated with diminished serum folate levels. Hence, in HNSCC low dietary intake of folate is associated with p16(INK4A) methylation, and this relat...Continue Reading

References

Sep 1, 1989·Head & Neck·M HsairiA Leclerc
Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·D M ParkinC S Muir
Jun 2, 1993·Journal of the National Cancer Institute·E GiovannucciW C Willett
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Apr 4, 2000·British Medical Bulletin·S J Duthie
Apr 6, 2000·Journal of the National Cancer Institute·M EstellerJ G Herman
Jan 25, 2002·The Bulletin of Tokyo Dental College·T YakushijiH Tanzawa
Sep 5, 2002·Head & Neck·Ana Escribano UzcudunJosé Gavilán Bouzas
Mar 6, 2003·Journal of the National Cancer Institute·Shumin M ZhangSusan E Hankinson
May 2, 2003·Annals of the New York Academy of Sciences·Sharon A Ross
Oct 29, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C PelucchiC La Vecchia
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Apr 20, 2004·International Journal of Cancer. Journal International Du Cancer·Shinichi ToyookaAdi F Gazdar
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Ana S NeumannQingyi Wei
Mar 1, 2005·Cancer Detection and Prevention·Madeleine A Kane
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Edward S PetersKarl T Kelsey
Mar 24, 2005·Cancer Metastasis Reviews·Lajos Döbrossy
Aug 2, 2005·Alcohol·Joel B Mason, Sang-Woon Choi

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Citations

May 17, 2008·HNO·P Schmezer, C Plass
Feb 16, 2012·Antioxidants & Redox Signaling·Anna LyYoung-In Kim
Apr 5, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D KawakitaH Tanaka
Nov 29, 2007·Journal of the National Cancer Institute·Katie M ApplebaumKarl T Kelsey
May 3, 2008·Cancer Research·Maria MaguireMark T Boyd
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mara S MeyerKarl T Kelsey
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Meng Hua TaoJo L Freudenheim
Sep 7, 2007·Environmental Health Perspectives·Thea M Edwards, John Peterson Myers
May 15, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Y B DingY X Wang
Dec 7, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Shams TabrezSyed Kashif Zaidi
Dec 21, 2010·Alcohol·Meng Hua TaoJo L Freudenheim
Nov 23, 2006·Leukemia Research·Gabriele BudaMario Petrini
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·C Sloane FurnissKarl T Kelsey
Jun 9, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Raghu RadhakrishnanKapaettu Satyamoorthy
Jun 15, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Meng Hua Tao, Jo L Freudenheim
Mar 21, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Samson ManiZdenko Herceg
Jun 23, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Justin A ColacinoLaura S Rozek
Dec 8, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mahin TafazoliSalmeh Dadgar
Jul 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paolo BossiElda Tagliabue
Sep 25, 2008·Ciência & saúde coletiva·Thea M Edwards, John Peterson Myers
Oct 10, 2015·The Journal of Nutrition·Lynn B BaileyDaniel J Raiten
Jul 30, 2020·Medicina·Andrea Maugeri, Martina Barchitta
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D KawakitaH Tanaka

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