Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets

Journal of Animal Science and Biotechnology
Tongxin WangFeiruo Huang

Abstract

The effects of dietary garcinol on diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets were investigated. One hundred forty four weaned piglets (Duroc × Yorkshire × Landrace) from 16 pens (9 piglets per pen) were randomly divided into four treatment groups: controls (CON) or those supplemented with 200 mg/kg (LOW), 400 mg/kg (MID), or 600 mg/kg (HIGH) diet garcinol. After 14-day trial, three piglets per pen were chosen to collect plasma, intestinal tissue and colonic digesta samples. We demonstrated for the first time that garcinol promoted growth performance, as increased average daily feed intake (ADFI) and decreased feed/gain ratio (F/G); and reduced diarrhea incidence (P < 0.05); and strengthened antioxidant capacity, as an increased antioxidative index (P < 0.05). Additionally, garcinol ameliorated intestinal barrier dysfunction, as an increased villus height to crypt depth ratio, increased zonula occludens protein 1 (ZO-1), occludin and claudin-1 expression in the jejunum and ileum (P < 0.05), and decreased intestinal permeability (P < 0.05); and reduced inflammation, as decreased cytokine interleukin (IL)-6, IL-10, IL-1β and tumor necrosis factor-α (TNF-α) levels in...Continue Reading

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Citations

Nov 4, 2020·Journal of the Science of Food and Agriculture·Dingfa WangGuanyu Hou
Feb 22, 2021·Cellular and Molecular Gastroenterology and Hepatology·Sweta GhoshVenkatakrishna Rao Jala
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Hyunjin KyoungMinho Song
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Jianyong ZhouJianjun Lu
Oct 8, 2021·Archives of Animal Nutrition·Marley Conceição Dos SantosAlex Maiorka

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Methods Mentioned

BETA
scraping
ELISA
PCR
electrophoresis
scrapings
MDA

Software Mentioned

Image
USEARCH
mothur
iCycler
QIIME
BLAST
UCLUST
Quantitative Insights Into Microbial Ecology ( QIIME
Pro
SPSS

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