Dietary glycemic index, glycemic load, and the risk of endometrial cancer: a case-control study and meta-analysis

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Carlotta GaleoneCarlo La Vecchia

Abstract

Carbohydrates and the dietary glycemic index (GI) influence insulin secretion and insulin-like growth factors, and may exert relevant effects on obesity and diabetes, both of which are important risk factors for endometrial cancer. We studied the association between dietary GI and glycemic load (GL) and endometrial cancer using data from an Italian case-control study. This included 454 women with histologically confirmed endometrial cancer and 908 controls admitted to the same hospitals for acute, non-neoplastic conditions. Multivariate odds ratios were obtained after allowance for major potential confounding factors, including noncarbohydrate energy intake. We updated a meta-analysis on this issue, including a recent US cohort study, which contributed about a quarter of all cases, besides our case-control study. In the case-control study, the odds ratios of endometrial cancer for the highest versus the lowest quintile were 1.03 [95% confidence interval (CI): 0.67-1.58] for GI and 1.01 (95% CI: 0.64-1.61) for GL. No heterogeneity was found across the strata of diabetes and other selected covariates. The summary risk estimate of endometrial cancer for the highest versus the lowest GI level, obtained from the meta-analysis, was 1...Continue Reading

Citations

May 10, 2013·Cancer Causes & Control : CCC·Melony G KingElisa V Bandera
Oct 29, 2015·The British Journal of Nutrition·Nitin ShivappaMarta Rossi
Feb 20, 2015·Molecular Nutrition & Food Research·Federica TuratiCarlo La Vecchia
Dec 18, 2014·Archives of Gynecology and Obstetrics·Youjin Je
Oct 5, 2019·Nutrients·Federica TuratiCarlo La Vecchia
Mar 6, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephanie C MelkonianXifeng Wu
Aug 28, 2021·Nutrients·Giovanna EspositoFederica Turati

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