Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet

Nutrients
Shima BibiMei-Jun Zhu

Abstract

Obesity is a risk factor for developing inflammatory bowel disease. Pea is unique with its high content of dietary fiber, polyphenolics, and glycoproteins, all of which are known to be health beneficial. We aimed to investigate the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis. Six-week-old C57BL/6J female mice were fed a 45% HFD or HFD supplemented with 10% GP. After 7-week dietary supplementation, colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period. GP supplementation ameliorated the disease activity index score in HFD-fed mice during the recovery stage, and reduced neutrophil infiltration, mRNA expression of monocyte chemoattractant protein-1 (MCP-1) and inflammatory markers interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ), and inducible nitric oxide synthase (iNOS) in HFD-fed mice. Further, GP supplementation increased mucin 2 content and mRNA expression of goblet cell differentiation markers including Trefoil factor 3 (Tff3), Krüppel-like factor 4 (Klf4), and SAM pointed domain ETS factor 1 (Spdef1) in HFD-fed mice. In addition, GP ameliorated endoplas...Continue Reading

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Citations

Oct 31, 2018·Journal of Cellular Physiology·Wenhua XueJie Zhao
Jul 14, 2020·World Journal of Gastroenterology : WJG·Aida KamalianAmir Hossein Abdolghaffari
Dec 29, 2020·Frontiers in Cellular Neuroscience·Ying HanLingling Zhu
May 1, 2021·Foods·Abigail Raffner BassonFabio Cominelli
Aug 29, 2021·Pharmaceuticals·Shijia PanYonggong Zhai

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Methods Mentioned

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Infrared Imaging

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General Linear Model of Statistical Analysis System

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