Dietary green tea extract increases phase 2 enzyme activities in protecting against myocardial ischemia-reperfusion

Nutrition Research
Masoumeh Akhlaghi, Brian Bandy

Abstract

Green tea catechins are dietary antioxidant compounds that have been shown to protect against myocardial ischemia-reperfusion (IR) injury. Considering reports that catechins can induce phase 2 enzymes in cultured cells and some organs, we hypothesized that part of the protection to heart against IR injury may involve elevation of phase 2 enzyme activities. Rats were fed for 10 days with either control diet (sham and control groups) or the diet mixed with 0.25% green tea extract. At the end of 10 days, hearts were excised and subjected to global ischemia for 20 min followed by reperfusion for 2 hours. The hearts were compared for indices of cell death, oxidative stress, and phase 2 enzyme activities. Hearts from the green tea group had a 65% to 85% decrease in markers of apoptosis, a tendency to higher total glutathione, and higher activities of the phase 2 enzymes glutamate cysteine ligase and quinone reductase. The results support a possible involvement of phase 2 enzymes in the protection by green tea catechins against myocardial IR injury.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Nov 1, 1996·Circulation Research·H Fliss, D Gattinger
Sep 28, 2001·British Journal of Anaesthesia·N MartiniW Schlack
Jun 20, 2003·Analytical Biochemistry·Collin C WhiteTerrance J Kavanagh
Sep 3, 2003·Biochemical and Biophysical Research Communications·Emanuela MasiniBruno Mondovì
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul A TownsendAnastasis Stephanou
Mar 21, 2006·Apoptosis : an International Journal on Programmed Cell Death·D-Y LiX L Ma
Jan 16, 2007·Cardiovascular Research·Martin Vila-PetroffAlicia Mattiazzi
Jan 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·Maria A PotenzaMonica Montagnani
Apr 13, 2007·Physiological Reviews·Preeti AhujaW Robb MacLellan
Jun 23, 2007·Current Medicinal Chemistry·R ZucchiS Evangelista
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Senri MiwaMasashi Komeda
Oct 2, 2007·Journal of the American College of Nutrition·Swen Wolfram
Dec 18, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hye-Kyung Na, Young-Joon Surh
Apr 9, 2008·Physiological Reviews·Elizabeth Murphy, Charles Steenbergen
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Katrina Go YamazakiFrancisco Villarreal
Jul 8, 2008·Molecular Aspects of Medicine·Shelly C Lu
Aug 12, 2008·Current Medicinal Chemistry·Pon Velayutham Anandh Babu, Dongmin Liu
Jun 24, 2009·Chemical Research in Toxicology·Małgorzata Muzolf-PanekIvonne M C M Rietjens

❮ Previous
Next ❯

Citations

Feb 11, 2014·Molecular and Cellular Biochemistry·Domenico LapennaFranco Cuccurullo
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Masoumeh Akhlaghi, Brian Bandy
Jun 17, 2016·Phytotherapy Research : PTR·Masoumeh Akhlaghi
Oct 11, 2016·International Journal of Cardiology·Beatriz B LustosaPaula S Azevedo
May 23, 2017·Nutrients·Rosanna MatteraRoberto Bei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis