Dietary hyperoxaluria is not reduced by treatment with lactic acid bacteria

Journal of Translational Medicine
Roswitha SienerBernd Hoppe

Abstract

Secondary hyperoxaluria either based on increased intestinal absorption of oxalate (enteric), or high oxalate intake (dietary), is a major risk factor of calcium oxalate urolithiasis. Oxalate-degrading bacteria might have beneficial effects on urinary oxalate excretion resulting from decreased intestinal oxalate concentration and absorption. Twenty healthy subjects were studied initially while consuming a diet normal in oxalate. Study participants were then placed on a controlled oxalate-rich diet for a period of 6 weeks. Starting with week 2 of the oxalate-rich diet, participants received 2.6 g/day of a lactic acid bacteria preparation for 5 weeks. Finally, subjects were examined 4 weeks after treatment while consuming again a normal-oxalate diet. Participants provided weekly 24-hour urine specimens. Analyses of blood samples were performed before and at the end of treatment. Urinary oxalate excretion increased significantly from 0.354 ± 0.097 at baseline to 0.542 ± 0.163 mmol/24 h under the oxalate-rich diet and remained elevated until the end of treatment, as did relative supersaturation of calcium oxalate. Plasma oxalate concentration was significantly higher after 5 weeks of treatment compared to baseline. Four weeks after...Continue Reading

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Citations

Dec 17, 2015·Journal of Medicinal Food·Roswitha SienerFrancisco Blanco
Jun 20, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·B PradereK Bensalah
Apr 4, 2015·The Veterinary Clinics of North America. Small Animal Practice·Donna M Raditic
Jun 19, 2017·Microbial Pathogenesis·Humaira SadafSyed Waqas Hassan
May 21, 2020·Nutrients·Milene S OrmanjiIta P Heilberg
Apr 18, 2018·Current Urology Reports·Kristina L Penniston, Stephen Y Nakada
Jul 25, 2018·International Urology and Nephrology·Roswitha SienerStefan Latz

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Software Mentioned

Statistical Package for the Social Sciences
EQUIL2
SPSS

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