Abstract
Indole-3-carbinol (I3C), found in cruciferous vegetables, has been shown to suppress or promote carcinogenesis depending on various animal models. Regarding its preventive effects, I3C acts as an anti-estrogen and can induce apoptosis, but precise mechanisms remain to be determined. Since I3C induces cytochrome P450 enzymes in the liver, it affects hydroxylation of estrogens and might therefore be expected to influence endometrial adenocarcinoma development. The present study was performed to clarify the effects of I3C using a rat two-stage endometrial carcinogenesis model, focusing on induction of cytochrome P450s and other estrogen-metabolic enzymes in the liver. First, to determine the estrogenic or anti-estrogenic activity, an uterotropic assay was conducted using ovariectomized Donryu rats (experiment 1). Second, to elucidate the effects on endometrial carcinogenicity, female Donryu rats initiated with a single dose of N-ethyl-N'-nitro-N-nitrosoguanidine into a uterine horn were fed 0 or 500 p.p.m. I3C in diets for 12 months (experiment 2). In experiment 3, similarly initiated animals received 0 or 2000 p.p.m. I3C in their diet, or 1 microg/kg 17beta-estradiol (E2) or 5 microg/kg 4-hydroxyestradiol (4HE) subcutaneously twi...Continue Reading
Citations
Jun 19, 2007·Nutrition and Cancer·Elisa V BanderaMarjorie L McCullough
Feb 3, 2007·Carcinogenesis·Susan C TiltonDavid E Williams
Aug 27, 2009·Carcinogenesis·Jing-Ru WengChing-Shih Chen
Aug 27, 2009·Molecular Pharmacology·Hany A OmarChing-Shih Chen
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gregory A ReedAryeh Hurwitz
Jan 25, 2013·Journal of Toxicologic Pathology·Midori YoshidaAkihiko Maekawa
Jul 2, 2014·Advances in Pharmacological Sciences·V L MaruthanilaS Mirunalini
Feb 10, 2016·Archives of Toxicology·Dagmar FaustCornelia Dietrich
Jul 24, 2012·The Journal of Nutritional Biochemistry·Seong-Ho LeeSeung Joon Baek
Jul 14, 2010·Cancer Epidemiology·Geoffrey C KabatThomas E Rohan
Dec 7, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·W J de WaardL A P Hoogenboom
Dec 7, 2007·Molecular Nutrition & Food Research·Gudrun C Rieck, Alison N Fiander
Jan 27, 2005·Biochemical and Biophysical Research Communications·Seong-Ho LeeSeung Joon Baek
Mar 31, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·David Y LaiWolfgang Dekant
Mar 22, 2015·Chemico-biological Interactions·Debasis NayakAnindya Goswami
Jan 30, 2015·Critical Reviews in Food Science and Nutrition·Venkidasamy BaskarShivraj Hariram Nile
Nov 7, 2016·Plant Physiology and Biochemistry : PPB·Dimitra KatsarouKalliope K Papadopoulou
Feb 14, 2012·Toxicologic Pathology·Michael C BoyleAbraham Nyska
Jul 13, 2011·Toxicologic Pathology·Midori YoshidaAkiyoshi Nishikawa
Jan 1, 2011·Cancers·Aamir AhmadKm Wahidur Rahman
Sep 30, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Susan C TiltonDavid E Williams
Nov 12, 2013·The Journal of Toxicological Sciences·Seigo HayashiMidori Yoshida
Nov 6, 2015·Journal of Toxicologic Pathology·Midori YoshidaMiwa Takahashi
Jul 5, 2013·The Journal of Toxicological Sciences·Kiyomitsu NemotoMasakuni Degawa
Aug 12, 2018·International Journal of Molecular Sciences·Tom Van NyenFrédéric Amant
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gregory A ReedAryeh Hurwitz
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lynne M HowellsMargaret M Manson
Jul 29, 2019·Molecular and Cellular Endocrinology·A D van den BrandM B M van Duursen