Dietary Inflammatory Index and Health Outcomes: An Umbrella Review of Systematic Review and Meta-Analyses of Observational Studies.

Frontiers in Nutrition
Fang-Hua LiuQi-Jun Wu

Abstract

Background and Aims: The dietary inflammatory index (DII) is associated with non-communicable disease. We conducted an umbrella review to systematically evaluate meta-analyses of observational studies on DII and diverse health outcomes. Methods: We comprehensively searched the PubMed, Web of Science, and Embase databases to identify related systematic reviews and meta-analyses of observational studies. Those investigating the association between DII and a wide range of health outcomes in humans were eligible for inclusion. For each meta-analysis, we estimated the summary effect size by using fixed and random effects models, the 95% confidence interval, and the 95% prediction interval. We assessed heterogeneity, evidence of small-study effects, and excess significance bias. Results: The umbrella review identified 35 meta-analyses assessing associations between DII and various health outcomes: cancer (n = 24), mortality (n = 4), metabolic (n = 4), and other (n = 3). The methodological quality was high or moderate. Of the 35 meta-analyses, we observed highly suggestive evidence for harmful associations between digestive tract cancer, colorectal cancer, overall cancer, pharyngeal cancer, UADT cancer, and CVD mortality. Moreover, 11...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 3, 2006·The American Journal of Psychiatry·Gordon ParkerDusan Hadzi-Pavlovic
Feb 17, 2007·BMC Medical Research Methodology·Beverley J SheaLex M Bouter
Mar 22, 2007·The Journal of Nutrition·Ahmad EsmaillzadehWalter C Willett
Aug 24, 2007·Clinical Trials : Journal of the Society for Clinical Trials·John P A Ioannidis, Thomas A Trikalinos
Jan 4, 2008·The New England Journal of Medicine·R H Belmaker, Galila Agam
Oct 4, 2008·International Journal of Epidemiology·Julian P T Higgins
Apr 22, 2009·Journal of the Royal Statistical Society. Series A, (Statistics in Society)·Julian P T HigginsDavid J Spiegelhalter
Dec 22, 2010·Irish Journal of Medical Science·J V ReynoldsS L Doyle
Apr 13, 2011·Acta Psychiatrica Scandinavica·B D Hegarty, G B Parker
Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Dec 5, 2012·Endocrine-related Cancer·Sefirin DjioguePaul Faustin Seke Etet
Aug 15, 2013·Public Health Nutrition·Nitin ShivappaJames R Hébert
Jul 22, 2014·Journal of Occupational and Environmental Medicine·Michael D WirthJames R Hébert
Feb 3, 2015·The British Journal of Nutrition·Nitin ShivappaInge Huybrechts
Apr 23, 2015·Annals of Epidemiology·Fred K TabungJames R Hebert
Sep 12, 2015·International Journal of Evidence-based Healthcare·Edoardo AromatarisPatraporn Tungpunkom
Oct 21, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L NeufcourtE Kesse-Guyot
Jan 8, 2016·Parkinsonism & Related Disorders·Vanesa BellouJohn P A Ioannidis
Mar 30, 2016·Annual Review of Nutrition·Carmen Sapienza, Jean-Pierre Issa
Apr 28, 2016·Seminars in Cancer Biology·Eswar ShankarSanjay Gupta
May 20, 2016·Annual Review of Pathology·Tuo DengWilla A Hsueh
Mar 2, 2017·BMJ : British Medical Journal·Maria KyrgiouKonstantinos K Tsilidis
Feb 15, 2018·Nutrients·Nitin ShivappaGiuseppe Grosso
May 4, 2018·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Nazli NamaziLeila Azadbakht
Jul 18, 2018·Atherosclerosis·Mohsen MazidiMaciej Banach
Aug 2, 2018·Research Synthesis Methods·Dean LanganMark Simmonds
Oct 16, 2018·Public Health Nutrition·Jian WangXinhua Hu
Jan 8, 2019·Advances in Nutrition·Sorayya Kheirouri, Mohammad Alizadeh
Aug 15, 2019·Nutrients·Catherine M PhillipsJames R Hébert
Sep 27, 2019·European Journal of Clinical Nutrition·Yi ZhuXin Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.