PMID: 2502415Jun 1, 1989Paper

Dietary influences on cell proliferation in bone marrow

European Journal of Cancer & Clinical Oncology
P B Dunki JacobsP W de Graaf

Abstract

Oral dietary protein-calorie malnutrition was used in rats to study the influence of malnutrition on the distribution of the dividing cells in the bone marrow (stem cells) over the compartments of the cell cycle. A 5-day period of malnutrition induced an increase in the percentage of cells in the G0/G1 phase of the cell cycle while simultaneously inducing a statistically significant decrease in the percentage of cells in S phase. Similar results were obtained after a 14-day period of malnutrition. Nutritional replenishment after 5 and 14 days of dietary deprivation induced a rapid recovery of the percentage of S phase cells and a decrease in the percentage of cells in the G0/G1 phase of the cell cycle. Malnutrition and nutritional replenishment did not influence hemoglobin concentration and platelet numbers in the peripheral blood, but leucocyte numbers increased significantly after short-term replenishment. These results demonstrate a decrease in the percentage of proliferating bone marrow cells after short periods of deficiency and general malnutrition. The results also demonstrate that bone marrow cells recover quickly after nutritional replenishment. In malnourished cancer patients, suspected of bone marrow insufficiency an...Continue Reading

References

Mar 1, 1989·European Journal of Cancer & Clinical Oncology·P B Dunki JacobsP W de Graaf
Oct 15, 1986·Cancer·D HeberR T Chlebowski
Jun 5, 1987·Science·S C Clark, R Kamen
Oct 15, 1986·Cancer·I L Bernstein
Mar 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·M FreemanM Valdivieso

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Citations

May 19, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P BorelliR A Fock
Aug 9, 2016·The Journal of Nutrition, Health & Aging·E FrangosF R Herrmann
Dec 29, 2009·Nutrition·Ricardo Ambrósio FockPrimavera Borelli

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