Dietary influences on endocrine-inflammatory interactions in prostate cancer development

Archives of Biochemistry and Biophysics
Emily HoTammy M Bray

Abstract

Prostate cancer is the most frequently diagnosed non-cutaneous cancer and is the second leading cause of cancer death in American men. The focus of this review is to define the relationship between hormonal (testosterone/estrogens) stimulation of chronic inflammation, generation of reactive oxygen species (ROS), and uncontrolled prostate cell proliferation, and review putative dietary chemoprevention strategies that focus on these processes. It has been proposed that elevated estrogen in men who already have high blood testosterone are at high risk for prostate cancer. We hypothesized that elevated estrogen, in the presence of testosterone, causes prolonged activation of a redox-sensitive transcription factor, nuclear factor kappa B (NF kappa B), that initiates and amplifies an inflammatory cascade within the prostate and results in sustained oxidative and nitrative damage. The inflammatory cascade is proposed to link with uncontrolled proliferation through up-regulated Wnt signal and abnormal catenin accumulation in the prostate. Finally, a strategy that emphasizes a "whole food" based approach to cancer prevention by selecting food products that bear anti-inflammatory and anti-proliferative properties may be most promising as...Continue Reading

References

May 30, 1975·Urological Research·R STIENSP Brühl
Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·M C Bosland
Oct 1, 1991·The Journal of Endocrinology·P Davies, C L Eaton
Jan 1, 1990·Free Radical Biology & Medicine·T M Bray, W J Bettger
Jan 1, 1989·The Prostate. Supplement·P Ekman
Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G LiehrK Randerath
Dec 6, 1995·Journal of the National Cancer Institute·E GiovannucciW C Willett
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S MunemitsuP Polakis
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW C Willett
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
Oct 1, 1993·The Journal of Cell Biology·P D McCreaB M Gumbiner
May 2, 1996·The New England Journal of Medicine·G S OmennS Hammar
Oct 1, 1996·Journal of the American Dietetic Association·K A Steinmetz, J D Potter
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
May 1, 1996·Nutrition·A S PrasadG J Brewer
Jul 1, 1997·The EMBO Journal·H AberleR Kemler
Oct 10, 1997·Journal of the American College of Nutrition·P ConnellB Hennig
May 30, 1998·Proceedings of the Society for Experimental Biology and Medicine·G R Beecher
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·J C ZhuangG N Wogan
Jul 21, 1999·Journal of the National Cancer Institute·M O RippleR Weindruch
Dec 14, 1999·The American Journal of Pathology·A M De MarzoW G Nelson

❮ Previous
Next ❯

Citations

Oct 7, 2005·Journal of Toxicology and Environmental Health. Part a·Eun Jeong Yoo, Byung Mu Lee
Jan 25, 2008·Acta Pharmacologica Sinica·Xiang-yun LiuZu-yue Sun
Feb 3, 2009·Cancer Letters·Lakshmipathi KhandrikaHari K Koul
Jun 21, 2008·International Journal of Cancer. Journal International Du Cancer·Timothy R RebbeckCharnita Zeigler-Johnson
Jun 11, 2009·International Journal of Andrology·B FibbiM Maggi
Oct 18, 2005·Biochimica Et Biophysica Acta·Joydeb Kumar KunduYoung-Joon Surh
Aug 23, 2005·Cancer Letters·Imtiaz A SiddiquiYogeshwer Shukla
Mar 7, 2013·Free Radical Biology & Medicine·Amélie RebillardJosiane Cillard
Dec 6, 2017·Prostate Cancer and Prostatic Diseases·Susanne M HenningWilliam J Aronson
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen J Freedland
Sep 1, 2007·Journal of Agricultural and Food Chemistry·Lavanya ReddivariJ Creighton Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis