Dietary intake, clinical-nutritional status, and homocysteine in hemodialysis subjects: the mediating role of inflammation (NUGE-HD study).

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Karla Pereira BalbinoHelen Hermana Miranda Hermsdorff

Abstract

The aim of the present study was to test the hypothesis that inflammation mediates the associations among food intake, clinical-nutritional status, and plasma homocysteine (Hcys) in hemodialysis (HD) subjects. This was a cross-sectional analysis of data on 129 subjects undergoing HD (58.9% male, 61.8 ± 15.5 years of age) from the cohort Nutrition and Genetics on HD outcomes (NUGE-HD study). Sociodemographic, anthropometric, and metabolic data were collected, and food intake was assessed using a quantitative food frequency questionnaire. Plasma C-reactive protein (CRP) was used as an inflammatory marker. Data were analyzed by structural equation modeling. Regarding the direct effects, complex B vitamin intake was negatively associated with body mass index, and diabetes mellitus was positively associated with CRP. Plasma CRP also showed a negative association with Hcys, and the ratio of saturated and polyunsaturated fatty acids intake showed a positive association with Hcys. Regarding indirect effects, the results showed that the relationship between the presence of diabetes mellitus and Hcys is mediated by plasma CRP. In conclusion, the ratio of saturated and polyunsaturated fatty acids had a direct effect on plasma Hcys, wherea...Continue Reading

References

Dec 4, 2001·Atherosclerosis·M C Audelin, J Genest
Mar 13, 2003·Kidney International·Kamyar Kalantar-ZadehJoel D Kopple
Mar 29, 2003·The American Journal of Clinical Nutrition·Vijay GanjiUNKNOWN Third National Health and Nutrition Examination Survey
Jul 16, 2003·Atherosclerosis·Aaron R FolsomLloyd E Chambless
Jul 29, 2004·Clinical Science·Rajesh UllegaddiSalah E Gariballa
Jun 13, 2006·Chemico-biological Interactions·Flore DepeintPeter J O'Brien
Jun 28, 2007·The Journal of International Medical Research·E HuskissonM Ruf
Sep 13, 2007·JAMA : the Journal of the American Medical Association·Rex L JamisonUNKNOWN Veterans Affairs Site Investigators
Feb 29, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincenzo PanichiUNKNOWN RISCAVID Study Group
Jun 19, 2008·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Arzu AkgulMehmet Haberal
Jan 9, 2010·Clinical Journal of the American Society of Nephrology : CJASN·George A Kaysen
Sep 14, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Kamyar Kalantar-ZadehGladys Block
Jan 19, 2011·Cadernos de saúde pública·Leila Denise Alves Ferreira AmorimMaurício L Barreto
Aug 27, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan BazeleyBruce M Robinson
Mar 8, 2013·Inflammation·Giuseppe DerosaPamela Maffioli
Mar 28, 2013·European Journal of Epidemiology·Valéria Troncoso BaltarPaolo Vineis
Nov 13, 2013·Cardiovascular Journal of Africa·Dudu SengwayoShirley Motaung
Dec 10, 2015·Annals of the New York Academy of Sciences·Jacob Selhub, Aron M Troen
Jun 24, 2016·American Journal of Physiology. Renal Physiology·Kun ZhangHui Huang
Mar 24, 2017·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K P BalbinoH H M Hermsdorff
Sep 15, 2017·Contributions to Nephrology·Lu DaiPeter Stenvinkel
Sep 15, 2017·Contributions to Nephrology·Magdalena JankowskaPeter Stenvinkel
May 10, 2019·Frontiers in Nutrition·Caterina TinelliMarco Feligioni

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