Dietary Intake of α-Linolenic Acid Is Not Appreciably Associated with Risk of Ischemic Stroke among Middle-Aged Danish Men and Women

The Journal of Nutrition
Christian S BorkKim Overvad

Abstract

Intake of the plant-derived omega-3 (n-3) fatty acid α-linolenic acid (ALA) may reduce the risk of ischemic stroke. We have investigated the associations between dietary intake of ALA and the risk of ischemic stroke and ischemic stroke subtypes. This was a follow-up study. A total of 57,053 participants aged 50-64 y were enrolled into the Danish Diet, Cancer and Health cohort between 1993 and 1997. Intake of ALA was assessed by a validated semiquantitative food frequency questionnaire. Potential incident cases of ischemic stroke were identified in the Danish National Patient Register, validated, and classified into subtypes based on assumed etiology. Statistical analyses were performed via Cox proportional hazard regression with adjustment for established ischemic stroke risk factors. A total of 1859 ischemic stroke cases were identified during a median of 13.5 y of follow-up. In multivariable analyses using restricted cubic splines adjusting for traditional risk factors for ischemic stroke, we observed no clear associations between dietary intake of ALA and the risk of total ischemic stroke or any of its subtypes including ischemic stroke due to large artery atherosclerosis, ischemic stroke due to small-vessel occlusion, and i...Continue Reading

Associated Clinical Trials

Aug 23, 2017·Christian Sørensen Bork

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Citations

Apr 16, 2019·The Proceedings of the Nutrition Society·Christian S BorkErik B Schmidt
Sep 25, 2019·International Journal of Molecular Sciences·Karina Cuanalo-Contreras, Ines Moreno-Gonzalez
Jun 30, 2019·Nutrients·Stine Krogh VenøChristian Sørensen Bork
Nov 22, 2020·Neurochemistry International·Bharath Chelluboina, Raghu Vemuganti
Nov 11, 2021·Journal of the American Heart Association·Neil K HuangAlice H Lichtenstein

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