Dietary Intake of Antioxidant Vitamins and Carotenoids and Risk of Developing Active Tuberculosis in a Prospective Population-Based Cohort Study

American Journal of Epidemiology
Avril Z SohWoon-Puay Koh

Abstract

Antioxidants may protect against oxidative stress, which is associated with tuberculosis (TB) disease. However, direct evidence for a protective association between dietary antioxidants and TB incidence in humans has been lacking. The relationship between intake of antioxidant vitamins (vitamins A, C, D, and E) and individual carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein) and TB incidence was examined in the Singapore Chinese Health Study, a prospective cohort study of 63,257 adults aged 45-74 years enrolled during 1993-1998. Baseline intake of these antioxidants was estimated using a validated semiquantitative food frequency questionnaire including questions on use of dietary supplements. After an average of 16.9 years of follow-up, 1,186 incident active TB cases were identified among cohort participants. Compared with the lowest quartile, reduced risk of active TB was observed for the highest quartile of vitamin A intake (hazard ratio = 0.71, 95% confidence interval: 0.59, 0.85; P-trend < 0.01) and β-carotene intake (hazard ratio = 0.76, 95% confidence interval: 0.63, 0.91; P-trend < 0.01), regardless of smoking status. Lower TB risk was seen for vitamin C intake among current smokers only. Other ...Continue Reading

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Citations

Jan 26, 2018·American Journal of Epidemiology·Avril Z SohWoon-Puay Koh
May 21, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wing-Wai YewYing Zhang
Apr 3, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wing W YewDenise P Chan
May 16, 2020·Tuberculosis Research and Treatment·Dawit A Ejigu, Solomon M Abay
Jan 6, 2021·Critical Reviews in Food Science and Nutrition·Saeid MaghsoudiThomas J Webster

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