Dietary intake of iodine-enriched eggs decreases the incidence of mouse mammary tumors caused by the activated ErbB2 oncogene

Animal Science Journal = Nihon Chikusan Gakkaihō
Kazunori OyamaTomokazu Fukuda

Abstract

Human epigenetic studies suggest that consumption of seaweed prevents mammary cancer, which possibly is explained by iodine daily intake. In this study, we evaluated the efficacy of dietary intake of iodine-enriched eggs on mammary tumor incidence caused by the expression of activated type ErbB2. Female transgenic mice were divided into three groups, and fed a basic diet, a diet supplemented with ordinary eggs, or with iodine-enriched eggs. The number of mammary tumors greater than 5 mm in diameter was recorded in mice at 6 months of age. We report that the average number of mammary tumors per mouse was significantly lower in the iodine-enriched egg-added diet group than in either the basic diet or ordinary egg diet groups. These results indicate that iodine intake through livestock-derived products can reduce the incidence of mammary cancers caused by the expression of activated type ErbB2.

References

Sep 1, 1967·The American Journal of Clinical Nutrition·J M Cooperman
Mar 1, 1996·Journal of Surgical Oncology·H FunahashiH Takagi
Nov 7, 1999·Japanese Journal of Cancer Research : Gann·H FunahashiT Narita
May 30, 2001·Japanese Journal of Cancer Research : Gann·H FunahashiS Tanuma
Dec 14, 2004·Thyroid : Official Journal of the American Thyroid Association·Jane TeasLewis E Braverman
Jul 23, 2008·International Journal of Medical Sciences·Frederick R StoddardGregg J Johannes
Jul 28, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·K OyamaK Nishimori
Mar 15, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Takehiro MichikawaUNKNOWN Japan Public Health Center-based Prospective Study Group
Feb 1, 2015·Japanese Journal of Clinical Oncology·Kota KatanodaHiroshi Nishimoto
Jun 28, 2015·Molecular Cancer Therapeutics·Defne YararGavin MacBeath
Sep 1, 2015·Critical Reviews in Oncology/hematology·María Teresa MartínezAna Lluch

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