Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies

BMJ : British Medical Journal
Sina NaghshiAhmad Esmaillzadeh

Abstract

To examine and quantify the potential dose-response relation between intake of total, animal, and plant protein and the risk of mortality from all causes, cardiovascular disease, and cancer. Systematic review and meta-analysis of prospective cohort studies. PubMed, Scopus, and ISI Web of Science until December 2019, and references of retrieved relevant articles. Prospective cohort studies that reported the risk estimates for all cause, cardiovascular, and cancer mortality in adults aged 18 or older. Random effects models were used to calculate pooled effect sizes and 95% confidence intervals for the highest versus lowest categories of protein intake and to incorporate variation between studies. Linear and non-linear dose-response analyses were done to evaluate the dose-response relations between protein intake and mortality. 32 prospective cohort studies were included in the systematic review and 31 in the meta-analysis. During the follow-up period of 3.5 to 32 years, 113 039 deaths (16 429‬ from cardiovascular disease and 22 303‬ from cancer) occurred among 715 128 participants. Intake of total protein was associated with a lower risk of all cause mortality (pooled effect size 0.94, 95% confidence interval 0.89 to 0.99, I2=58....Continue Reading

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Citations

Nov 8, 2020·Heart, Lung & Circulation·Paul J NestelTrevor A Mori
Nov 25, 2020·Geriatrics·Carla PignattiSilvia Cetrullo
Nov 14, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Paul J NestelTrevor A Mori
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Apr 4, 2021·Nutrients·Susana SantiagoMiguel Ángel Martínez-González
Apr 6, 2021·Frontiers in Endocrinology·Ximena M Bustamante-MarinDelisha A Stewart
Apr 15, 2021·Deutsche medizinische Wochenschrift·Thomas Münzer
May 18, 2021·PloS One·Miguel A Fernández-BlázquezJaime Gómez-Ramírez
Jun 3, 2021·Foods·Maite M AldayaMaría José Beriain
Feb 3, 2021·Panminerva Medica·Elio VenturiniFrancesco Giallauria
Jul 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuan LiMing Cui
Oct 29, 2021·Food & Function·Dinuerguli YishakeHui-Lian Zhu
Sep 16, 2021·The American Journal of Clinical Nutrition·Jessica FanzoWalter C Willett

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