Dietary Intake of Whole Strawberry Inhibited Colonic Inflammation in Dextran-Sulfate-Sodium-Treated Mice via Restoring Immune Homeostasis and Alleviating Gut Microbiota Dysbiosis

Journal of Agricultural and Food Chemistry
Yanhui HanHang Xiao

Abstract

Strawberry (Fragaria chiloensis) is a major edible berry with various potential health benefits. This study determined the protective effects of whole strawberry (WS) against dextran-sulfate-sodium-induced colitis in mice. In colitic mice, dietary WS reduced the disease activity index, prevented the colon shortening and spleen enlargement, and alleviated the colonic tissue damages. The abundance of proinflammatory immune cells was reduced by dietary WS in the colonic mucosa, which was accompanied by the suppression of overproduction of proinflammatory cytokines. Western blotting and immunohistochemical analysis revealed that dietary WS decreased the expression of proinflammatory proteins in the colonic mucosa. Moreover, dietary WS partially reversed the alteration of gut microbiota in the colitic mice by increasing the abundance of potential beneficial bacteria, e.g., Bifidobacterium and Lactobacillus, and decreasing the abundance of potential harmful bacteria, e.g., Dorea and Bilophila. Dietary WS also restored the decreased production of short-chain fatty acids in the cecum of the colitic mice. The results revealed the anti-inflammatory effects and mechanisms of dietary WS in the colon, which is critical for the rational util...Continue Reading

References

Sep 1, 1986·The Journal of Nutrition·T Høverstad, T Midtvedt
Mar 21, 2001·Cellular Signalling·M Guha, N Mackman
Jul 20, 2002·Free Radical Biology & Medicine·Kevin P PavlickMatthew B Grisham
Jan 31, 2003·European Journal of Immunology·Shunya SasakiShosaku Narumi
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Madeline M FortRobert M Hershberg
Jun 28, 2006·Nutrition and Cancer·Geeta LalaBernadene A Magnuson
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
May 23, 2009·Inflammatory Bowel Diseases·Christine A Chapman-KiddellGraham L Radford-Smith
Mar 2, 2011·The American Journal of Pathology·Allisson Freire BentoJoão B Calixto
Mar 16, 2011·International Journal of General Medicine·Pietro Ghezzi
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Jul 9, 2011·The British Journal of Nutrition·Indika EdirisingheBritt M Burton-Freeman
Oct 14, 2011·Nature Immunology·Vladimir Ramirez-CarrozziRajita Pappu
Mar 3, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giuseppe D'ArgenioMarco Romano
Jun 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martina E SpehlmannLars Eckmann
Jul 31, 2013·Molecular Nutrition & Food Research·Jinkai ZhengHang Xiao
Sep 10, 2013·Nutrition·Shivraj Hariram Nile, Se Won Park
Mar 19, 2014·Cell Host & Microbe·Dirk GeversRamnik J Xavier
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Nov 2, 2017·The Journal of Nutritional Biochemistry·Shima BibiMei-Jun Zhu

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Citations

Jan 18, 2020·Annual Review of Food Science and Technology·Yanhui Han, Hang Xiao
Jan 26, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Maurizio BattinoTamara Forbes-Hernández
Feb 18, 2021·Comprehensive Reviews in Food Science and Food Safety·Dongmei WuShiguo Chen
Jun 23, 2019·European Journal of Pharmacology·Kanyasiri RakariyathamHang Xiao
Apr 2, 2021·Critical Reviews in Food Science and Nutrition·Gaoxing MaHang Xiao
Jul 25, 2019·Journal of Agricultural and Food Chemistry·Francisco Tomas-Barberán, Coralia Osorio

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