Dietary intake, smoking, and transient anti-gliadin antibodies

Scandinavian Journal of Gastroenterology
S A McMillanA E Evans

Abstract

The detection of IgA anti-gliadin antibodies in adults can either be helpful in the diagnosis of coeliac disease, be persistent in subjects with normal jejunal mucosa, or occur transiently. We decided to investigate the effects of smoking, alcohol consumption, and dietary intake on the development of IgA anti-gliadin antibodies. Serum samples from subjects enrolled from a large Northern Ireland population sample (MONICA survey) were screened for IgA anti-endomysium and IgA anti-gliadin antibodies. All subjects with positive antibodies were invited for clinical assessment 3-4 years after the initial screening sample. During this follow-up a repeat serum sample was obtained and a jejunal biopsy performed. At enrollment in the MONICA survey, lifestyle information including smoking, alcohol consumption, and dietary intake was obtained. At follow-up 13 subjects had persistent positive serology and villous atrophy, and 9 had persistent positive serology but normal jejunal histology; in 29 the serology had returned to normal, and the jejunal histology was normal There was no difference in smoking, alcohol consumption, or dietary intake between subjects with and without coeliac disease. Subjects with transient serology findings ate sig...Continue Reading

References

Sep 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·V KumarE Lebenthal
Jan 22, 1994·Lancet·C CatassiP L Giorgi
Jul 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·B WeileP A Krasilnikoff

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Citations

Jun 10, 2011·The Journal of Investigative Dermatology·Jonas F LudvigssonCarolina Ciacci
Feb 22, 2012·International Journal of Dermatology·Arisa Ortiz, Sergei A Grando
Apr 30, 2005·Acta Paediatrica·J F Ludvigsson, UNKNOWN ABIS Study Group
Mar 10, 2000·The American Journal of Gastroenterology·W DickeyS A McMillan
Apr 12, 2006·European Journal of Gastroenterology & Hepatology·Martin W LaassJobst Henker
Mar 17, 2000·Scandinavian Journal of Gastroenterology·W DickeyS A McMillan
Jul 21, 2000·Annals of Clinical Biochemistry·S D JohnstonA H Love

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