Dietary intakes of flavan-3-ols and cardiovascular health: a field synopsis using evidence mapping of randomized trials and prospective cohort studies

Systematic Reviews
Gowri RamanAedín Cassidy

Abstract

There is considerable interest in the impact of increased flavan-3-ol intake on cardiovascular disease (CVD) and diabetes outcomes. Through evidence mapping, we determined the extent of the evidence base to initiate a future systematic review investigating the impact of flavan-3-ol intake on CVD and diabetes outcomes. We developed a research protocol, convened a technical expert panel (TEP) to refine the specific research questions, conducted a systematic search in multiple databases, double-screened abstracts and full-text articles, performed data extractions, and synthesized the data. We focused on randomized controlled trials (RCTs) and prospective cohort studies which assessed intakes of flavan-3-ol from foods, beverages, and supplement/extract sources on biomarkers and clinical outcomes of CVD and diabetes. Of 257 eligible articles, 223 and 34 publications contributed to 226 RCTs and 39 prospective cohort studies, respectively. In RCTs, the most frequently studied interventions were cocoa-based products (23.2%); berries (16.1%); tea in the form of green tea (13.9%), black tea (7.2%), or unspecified tea (3.6%); and red wine (11.2%). Mean total flavan-3-ol intake was highest in the cocoa-based trials (618.7 mg/day) and lowes...Continue Reading

References

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Citations

Sep 25, 2019·Nutrients·Estefanía Márquez CamposMarie-Christine Simon
Apr 21, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Alexandre de Souza da SilvaDayane Teixeira Ognibene
Oct 16, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Esther E Avendano, Gowri Raman
May 1, 2021·Antioxidants·Mindaugas LiaudanskasValdimaras Janulis
May 8, 2021·Advances in Nutrition·Allison A YatesUNKNOWN serving as an ad hoc Working Group on a Framework for Developing Recommended Intakes for Dietary Bioactives
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sinenhlanhla X H MthembuSithandiwe E Mazibuko-Mbeje

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