Dietary iron interacts with genetic background to influence glucose homeostasis

Nutrition & Metabolism
Mario A MirandaHeather A Lawson

Abstract

Iron is a critical component of metabolic homeostasis, but consumption of dietary iron has increased dramatically in the last 30 years, corresponding with the rise of metabolic disease. While the link between iron metabolism and metabolic health is well established, the extent to which dietary iron contributes to metabolic disease risk is unexplored. Further, it is unknown how dietary iron interacts with genetic background to modify metabolic disease risk. LG/J and SM/J inbred mouse strains were used to investigate the relationship between genetic background and metabolic function during an 8-week high iron diet. Glucose tolerance and adiposity were assessed, colorimetric assays determined levels of circulating metabolic markers, and hepatic iron content was measured. RNA sequencing was performed on white adipose tissue to identify genes differentially expressed across strain, diet, and strain X diet cohorts. Hepatic Hamp expression and circulating hepcidin was measured, and small nucleotide variants were identified in the Hamp genic region. LG/J mice experienced elevated fasting glucose and glucose intolerance during the high iron diet, corresponding with increased hepatic iron load, increased circulating ferritin, and signs o...Continue Reading

References

Jul 30, 2002·Diabetes·José Manuel Fernández-RealWifredo Ricart
Sep 29, 2004·Diabetes Care·Megan JehnEliseo Guallar
May 9, 2007·Nucleic Acids Research·Andreas UntergasserJack A M Leunissen
May 12, 2007·Blood Cells, Molecules & Diseases·Richard S AjiokaJames P Kushner
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Apr 18, 2009·Biochemical and Biophysical Research Communications·Henry K Bayele, Surjit K S Srai
Jan 30, 2010·Bioinformatics·Aaron R Quinlan, Ira M Hall
Apr 1, 2010·American Journal of Physiology. Endocrinology and Metabolism·Robert C CookseyDonald A McClain
Jun 12, 2010·Obesity·James M CheverudClay F Semenkovich
Jan 7, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heather A LawsonJames M Cheverud
Sep 22, 2012·The Journal of Clinical Investigation·J Scott GabrielsenDonald A McClain
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Apr 13, 2013·The American Journal of Pathology·Paola DongiovanniLuca Valenti
May 7, 2013·The Journal of Nutritional Biochemistry·Joo Sun ChoiJihyun Song
Oct 16, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Terrence C H TanLinda M Fletcher
Jun 30, 2014·Diabetologia·José María Moreno-NavarreteJosé Manuel Fernández-Real
Aug 25, 2015·The Journal of Clinical Investigation·Yan GaoDonald A McClain
Apr 14, 2016·Genome Biology·Robert BuelsIan H Holmes
Dec 3, 2016·Nucleic Acids Research·Minoru KanehisaKanae Morishima
Jan 26, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H A LawsonC F Semenkovich
Oct 12, 2018·Nutrients·Mario A Miranda, Heather A Lawson

❮ Previous
Next ❯

Citations

Sep 13, 2019·Nutrients·Lipika SalayeDonald A McClain
Oct 25, 2020·International Journal of Molecular Sciences·Carine FillebeenKostas Pantopoulos

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
RNAseq
Chip

Software Mentioned

BEDtools
Python
Ensembl
STAR aligner
DAVID
STAR
custom
edgeR
JBrowse

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Related Papers

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Gautam RishiV Nathan Subramaniam
The American Journal of Clinical Nutrition
Gregory J Anderson, David M Frazer
© 2022 Meta ULC. All rights reserved