Dietary krill oil enhances neurocognitive functions and modulates proteomic changes in brain tissues of d-galactose induced aging mice

Food & Function
Ling-Zhi CheongXiurong Su


The effects of dietary krill oil on neurocognitive functions and proteomic changes in brain tissues of d-galactose-induced aging mice were evaluated. Dietary krill oil enhanced the neurocognitive functions of aging mice with a significant (P < 0.05) decrease in escape latency and an increase in the number of times of crossing over the hidden platform during the Morris water maze test. Krill oil was also found to protect against oxidative damage, lipid peroxidation and neurodegenerative diseases. Oxidative stress biomarkers of aging mice administered with krill oil showed significant (P < 0.05) improvement with an increase in serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels; there were insignificant changes in the serum malondialdehyde (MDA) level. In terms of proteomic changes, krill oil resulted in upregulation of the Celsr3 and Ppp1r1b gene expression, which contribute to brain development, learning and memory behavior processes. In particular, the Ppp1r1b gene is associated with the inhibition of dopamine releases, which decreases the motivation for learning.


Jan 1, 1997·Free Radical Biology & Medicine·W R Markesbery
Mar 22, 2001·Nature Reviews. Neuroscience·W Schultz
Aug 8, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·W Schultz
Jan 25, 2003·Experimental Gerontology·C A Erickson, C A Barnes
May 31, 2003·The Journal of Biological Chemistry·Laura J NiedernhoferLawrence J Marnett
Dec 20, 2003·Behavioural Brain Research·Victor H DenenbergRichard D Palmiter
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Per SvenningssonPaul Greengard
Jan 11, 2005·Behavioural Brain Research·Haifeng WeiWei Li
Mar 22, 2005·Nature Neuroscience·Fadel TissirAndre M Goffinet
Mar 10, 2007·Nutrition Reviews·Janet C TouYi-Chen Chen
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Jan 26, 2011·Ageing Research Reviews·Sónia C CorreiaMark A Smith
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heidi A JurgensRodney W Johnson
Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jia FengLibing Zhou
Apr 2, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Birgit BölckWilhelm Bloch
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yibo QuAndre M Goffinet
Feb 12, 2015·British Journal of Pharmacology·Jean-Martin BeaulieuRaul R Gainetdinov

❮ Previous
Next ❯


Mar 7, 2018·Scientific Reports·M Carmen CrespoFrancesco Visioli
Nov 30, 2018·The Journal of Obstetrics and Gynaecology Research·Ilkin YeralOzcan Erel
Sep 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji Hyun KimEun Ju Cho
Aug 24, 2019·Progress in Lipid Research·Tian-Tian ZhangChang-Hu Xue
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·Mirja Kaizer AhmmedAlaa El-Din Bekhit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.