Dietary L-arginine supplementation enhances the immune status in early-weaned piglets

Amino Acids
Bie TanGuoyao Wu

Abstract

This study was conducted to test the hypothesis that dietary L-arginine supplementation enhances immunity in early weaned piglets. Seventy piglets weaned at 7 days of age were assigned to five groups (14 pigs/group), representing supplementation of 0.0, 0.2, 0.4, 0.6, and 0.8% L-arginine to a milk-based formula. On Day 7 after initiation of treatment, spleen weight in piglets supplemented with 0.2 and 0.8% arginine was heavier and thymus size was larger in piglets supplemented with 0.6% arginine, whereas serum concentration of immunoglobulin (Ig) M was higher but that of IL-8 was lower in piglets supplemented with 0.6 and 0.8% arginine, compared with the control group. Dietary supplementation with 0.8% arginine increased the numbers of white blood cells and granulocytes, and gene expression of interleukin (IL)-8 in spleen. On Day 14, compared with control piglets, granulocyte numbers were greater but lymphocyte numbers were lower in piglets supplemented with 0.2 and 0.4% arginine, whereas splenic expression of IL-8 and tumor necrosis factor-alpha genes was increased in piglets supplemented with 0.8% arginine. Additionally, IgG and IgM concentrations in serum and growth performance were greater in piglets supplemented with 0.4-0...Continue Reading

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Citations

Nov 26, 2008·Amino Acids·Guoyao WuYulong Yin
Mar 21, 2009·Amino Acids·Guoyao Wu
Jan 29, 2013·The British Journal of Nutrition·Wenkai RenYulong Yin
Aug 1, 2013·Journal of Animal Science and Biotechnology·Megan R Ruth, Catherine J Field
Mar 1, 2013·Journal of Animal Science and Biotechnology·Reza RezaeiGuoyao Wu
Dec 18, 2013·The British Journal of Nutrition·Jianzhuang TanSusan D Eicher
Mar 20, 2010·Amino Acids·Zhao-Lai DaiWei-Yun Zhu
Sep 16, 2010·Amino Acids·Xilong LiGuoyao Wu
Feb 1, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Xiao-jun ZhangDavid N Herndon
Nov 11, 2014·Annual Review of Animal Biosciences·Guoyao WuZhenlong Wu
Aug 24, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Iara Eliza Pacífico QuirinoMaria Isabel Toulson Davisson Correia
Dec 4, 2016·Annual Review of Animal Biosciences·Bie Tan, Yulong Yin

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