Dietary l-threonine supplementation attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage of broiler chickens at an early age

The British Journal of Nutrition
Yueping ChenYanmin Zhou

Abstract

This study was conducted to investigate the protective effects of l-threonine (l-Thr) supplementation on growth performance, inflammatory responses and intestinal barrier function of young broilers challenged with lipopolysaccharide (LPS). A total of 144 1-d-old male chicks were allocated to one of three treatments: non-challenged broilers fed a basal diet (control group), LPS-challenged broilers fed a basal diet without l-Thr supplementation and LPS-challenged broilers fed a basal diet supplemented with 3·0 g/kg l-Thr. LPS challenge was performed intraperitoneally at 17, 19 and 21 d of age, whereas the control group received physiological saline injection. Compared with the control group, LPS challenge impaired growth performance of broilers, and l-Thr administration reversed LPS-induced increase in feed/gain ratio. LPS challenge elevated blood cell counts related to inflammation, and pro-inflammatory cytokine concentrations in serum (IL-1β and TNF-α), spleen (IL-1β and TNF-α) and intestinal mucosa (jejunal interferon-γ (IFN-γ) and ileal IL-1β). The concentrations of intestinal cytokines in LPS-challenged broilers were reduced by l-Thr supplementation. LPS administration increased circulating d-lactic acid concentration, where...Continue Reading

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Citations

May 20, 2020·Environmental Science and Pollution Research International·Yueping ChenYanmin Zhou
Dec 18, 2020·Animals : an Open Access Journal From MDPI·Janghan Choi, Woo Kyun Kim
Jun 12, 2021·Frontiers in Veterinary Science·Tristan Chalvon-DemersayEtienne Corrent
Dec 29, 2021·Stress : the International Journal on the Biology of Stress·Victoria Anthony UyangaHai Lin

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