Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies

Scientific Reports
Beibei ZhuXiaoping Miao

Abstract

Previous epidemiological studies on the relation between dietary legume consumption and risk of colorectal cancer (CRC) remain controversial. We conducted a meta-analysis based on prospective cohort studies to investigate the association between dietary legume consumption and risk of CRC. Fourteen cohort studies were finally included, containing a total of 1,903,459 participants and 12,261 cases who contributed 11,628,960 person-years. We found that higher legume consumption was associated with a decreased risk of CRC (RR, relative risk = 0.91; 95% CI, confidence interval = 0.84-0.98). Subgroup analyses suggested that higher legume consumption was inversely associated with CRC risk in Asian (RR = 0.82; 95% CI = 0.74-0.91) and soybean intake was associated with a decreased risk of CRC (RR = 0.85; 95% CI = 0.73-0.99). Findings from our meta-analysis supported an association between higher intake of legume and a reduced risk of CRC. Further studies controlled for appropriate confounders are warranted to validate the associations.

References

Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·B Armstrong, R Doll
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1994·American Journal of Epidemiology·K A SteinmetzJ D Potter
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 24, 1998·American Journal of Epidemiology·P N Singh, G E Fraser
Aug 17, 1999·Annual Review of Nutrition·M LipkinS A Lamprecht
Sep 9, 1999·The American Journal of Clinical Nutrition·M J Messina
Nov 4, 2000·Journal of the National Cancer Institute·K B MichelsW C Willett
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 23, 2003·The American Journal of Gastroenterology·Joseph C AndersonDouglas L Brand
Apr 22, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·S Kono
Sep 8, 2004·International Journal of Cancer. Journal International Du Cancer·Faye TurnerJennifer H Barrett
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sheila A BinghamElio Riboli
Apr 6, 2006·Cancer Research·Karin B MichelsWalter C Willett
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Aurélie MoskalElio Riboli
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kenji WakaiUNKNOWN JACC Study Group
May 9, 2007·American Journal of Epidemiology·Yikyung ParkArthur Schatzkin
May 11, 2007·The American Journal of Clinical Nutrition·Arthur SchatzkinFrances E Thompson
Jun 9, 2007·Cancer Causes & Control : CCC·Abraham M Y NomuraLaurence N Kolonel
Jun 19, 2007·Nutrition and Cancer·Shino ObaShogen Matsushita
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Munira AkhterUNKNOWN Japan Public Health Center-Based Prospective Study Group
Dec 17, 2008·The American Journal of Clinical Nutrition·Gong YangWei Zheng
Apr 8, 2009·International Journal of Cancer. Journal International Du Cancer·Rachel R HuxleyMark Woodward
Nov 10, 2009·CA: a Cancer Journal for Clinicians·Melissa M CenterElizabeth Ward
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lin YanMaarten C Bosland
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Susanna C LarssonAlicja Wolk
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 29, 2011·Critical Reviews in Toxicology·Susanne AndresAlfonso Lampen
Aug 30, 2010·Archives of Medical Science : AMS·Katarzyna Smolińska, Piotr Paluszkiewicz
Aug 24, 2012·Journal of the National Cancer Institute·Terry BoyleLin Fritschi
Nov 13, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rikke Dalgaard HansenOle Raaschou-Nielsen
Nov 26, 2013·Nutrition Research·Eunjung KimFrançois Blachier
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Rakhi Kumari Joshi, Sang-Ah Lee

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Citations

Mar 12, 2016·Clinical Colorectal Cancer·Veronica AranCarlos Gil Ferreira
Apr 30, 2016·Critical Reviews in Food Science and Nutrition·Cem EkmekciogluHans-Peter Hutter
Sep 13, 2018·Journal of Cellular Physiology·Rahul MittalVasanti M Jhaveri
Jun 24, 2017·Scientific Reports·Demin LuSuzhan Zhang
May 3, 2020·The American Journal of Clinical Nutrition·Yuan ZhongLin Miao
Jun 27, 2020·Food & Function·Davide PanzeriMaria Elena Regonesi
Mar 17, 2019·Nutrients·Saeed Mastour AlshahraniMichael J Orlich
Apr 18, 2017·AIMS Microbiology·Luis R SilvaEncarna Velázquez
Feb 6, 2021·International Journal of Food Sciences and Nutrition·Daniela MartiniGiuseppe Grosso
Nov 11, 2020·Journal of Agricultural and Food Chemistry·Alba Tor-RocaMireia Urpi-Sarda
Oct 31, 2018·Journal of Agricultural and Food Chemistry·Alaeddine ChoucheneValerie Lullien-Pellerin

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