Dietary Leucine Supplementation Improves the Mucin Production in the Jejunal Mucosa of the Weaned Pigs Challenged by Porcine Rotavirus

PloS One
Xiangbing MaoPing Zheng

Abstract

The present study was mainly conducted to determine whether dietary leucine supplementation could attenuate the decrease of the mucin production in the jejunal mucosa of weaned pigs infected by porcine rotavirus (PRV). A total of 24 crossbred barrows weaned at 21 d of age were assigned randomly to 1 of 2 diets supplemented with 1.00% L-leucine or 0.68% L-alanine (isonitrogenous control) for 17 d. On day 11, all pigs were orally infused PRV or the sterile essential medium. During the first 10 d of trial, dietary leucine supplementation could improve the feed efficiency (P = 0.09). The ADG and feed efficiency were impaired by PRV infusion (P<0.05). PRV infusion also increased mean cumulative score of diarrhea, serum rotavirus antibody concentration and crypt depth of the jejunal mucosa (P<0.05), and decreased villus height: crypt depth (P = 0.07), goblet cell numbers (P<0.05), mucin 1 and 2 concentrations (P<0.05) and phosphorylated mTOR level (P<0.05) of the jejunal mucosa in weaned pigs. Dietary leucine supplementation could attenuate the effects of PRV infusion on feed efficiency (P = 0.09) and mean cumulative score of diarrhea (P = 0.09), and improve the effects of PRV infusion on villus height: crypt depth (P = 0.06), goblet...Continue Reading

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Citations

Jan 28, 2017·Journal of Animal Science and Biotechnology·Shihai ZhangShiyan Qiao
Jun 5, 2019·Animals : an Open Access Journal From MDPI·Qi MouPeng-Fei Huang
Nov 23, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Hua ZhouDaiwen Chen
Dec 12, 2018·Applied Microbiology and Biotechnology·Feng ZhangWen Yao
Mar 23, 2021·Journal of Animal Science and Biotechnology·Xiangqi FanXiangbing Mao
Jun 12, 2021·Frontiers in Veterinary Science·Tristan Chalvon-DemersayEtienne Corrent

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Methods Mentioned

BETA
scraping
ELISA
enzyme-linked immunosorbent assay

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