Dietary, lifestyle, and clinical predictors of lipoprotein-associated phospholipase A2 activity in individuals without coronary artery disease.

The American Journal of Clinical Nutrition
Ida J HatoumEric B Rimm

Abstract

Elevated lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) may be positively associated with risk of coronary artery disease, yet little is known about potentially modifiable factors related to Lp-PLA(2). The aim of this study was to determine dietary, lifestyle, and clinical measures associated with Lp-PLA(2) activity. We measured Lp-PLA(2) activity in 853 female participants of the Nurses' Health Study and 878 male participants of the Health Professionals Follow-Up Study who were free of cancer and cardiovascular disease. Multivariable linear regression models were used to assess the relation between potentially modifiable factors and Lp-PLA(2). The replacement of 5% of energy from carbohydrates with energy from protein was associated with 2.2 nmol . min(-1) . mL(-1) lower levels of Lp-PLA(2) (95% CI: -3.1, -0.4) activity, and every 15-g/d increase in alcohol consumption was associated with 4.4 nmol . min(-1) . mL(-1) lower levels of Lp-PLA(2) activity (95% CI: -6.4, -2.4). Smoking (beta = 10.2; 95% CI: 4.8, 15.5), being overweight (beta = 7.5; 95% CI: 3.6, 11.3), aspirin use (beta = 6.0; 95% CI: 2.1, 10.0), hypercholesterolemia (beta = 15.0; 95% CI: 11.3, 18.8), and age (beta = 2.5; 95% CI: 1.34, 3.74) were associated wi...Continue Reading

References

Apr 15, 1991·American Journal of Epidemiology·E GiovannucciW C Willett
Mar 25, 1989·BMJ : British Medical Journal·W Y CraigJ E Haddow
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M YokodeM Fujiwara
Jul 1, 1985·American Journal of Epidemiology·W C WillettF E Speizer
Jul 1, 1993·Journal of the American Dietetic Association·D FeskanichW C Willett
Jul 30, 1999·Biochemical and Biophysical Research Communications·K AsanoK Yamaguchi
Jul 17, 2003·Current Opinion in Lipidology·Muriel J Caslake, Chris J Packard
Dec 1, 1950·Biometrika·W G COCHRAN
Oct 23, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos IribarrenCatherine M Loria
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew Zalewski, Colin Macphee
Oct 22, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Eric H YangAmir Lerman
Dec 24, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Isabella KardysJacqueline C M Witteman
Aug 12, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Yariv GerberVéronique L Roger
Sep 5, 2006·The American Journal of Cardiology·Alfred A Bartolucci, George Howard
Oct 25, 2006·Archives of Internal Medicine·Mitchell S V ElkindRalph L Sacco
Oct 31, 2006·Journal of Diabetes and Its Complications·Hiroshi NotoPhilip Raskin
Jun 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shao-Yan ZhangToru Nabika
Sep 4, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Marc S SabatineUNKNOWN PEACE Investigators
Mar 28, 2008·Journal of the American Geriatrics Society·Curt D FurbergBruce M Psaty
Jun 11, 2008·Archives of Internal Medicine·Edward GiovannucciEric B Rimm
Sep 4, 2008·Circulation·Patrick W SerruysUNKNOWN Integrated Biomarker and Imaging Study-2 Investigators

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Citations

Aug 27, 2011·Current Atherosclerosis Reports·Cheuk-Kit Wong, Harvey D White
Feb 22, 2012·Current Atherosclerosis Reports·Eliot A Brinton
Mar 5, 2013·Current Treatment Options in Cardiovascular Medicine·Koto Ishida, Brett Cucchiara
Jul 10, 2010·Current Opinion in Lipidology·Eliot A Brinton
Oct 1, 2011·Lipids in Health and Disease·Isis T SilvaNágila R T Damasceno
Mar 10, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Oana VittosElena Moldoveanu
Sep 11, 2012·European Journal of Clinical Investigation·Alexander ConstantinidesRobin P F Dullaart
Mar 19, 2014·European Journal of Nutrition·P DetopoulouS Antonopoulou
Feb 15, 2020·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Seyed Hashem Sezavar SeyediFereidoun Azizi

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