Dietary linoleic acid and polyunsaturated fatty acids in rat brain and other organs. Minimal requirements of linoleic acid

Lipids
J M BourreG Durand

Abstract

Starting three weeks before mating, 12 groups of female rats were fed different amounts of linoleic acid (18:2n-6). Their male pups were killed when 21-days-old. Varying the dietary 18:2n-6 content between 150 and 6200 mg/100 g food intake had the following results. Linoleic acid levels remained very low in brain, myelin, synaptosomes, and retina. In contrast, 18:2n-6 levels increased in sciatic nerve. In heart, linoleic acid levels were high, but were not related to dietary linoleic acid intake. Levels of 18:2n-6 were significantly increased in liver, lung, kidney, and testicle and were even higher in muscle and adipose tissue. On the other hand, in heart a constant amount of 18:2n-6 was found at a low level of dietary 18:2n-6. Constant levels of arachidonic acid (20:4n-6) were reached at 150 mg/100 g diet in all nerve structures, and at 300 mg/100 g diet in testicle and muscle, at 800 mg/100 g diet in kidney, and at 1200 mg/100 g diet in liver, lung, and heart. Constant adrenic acid (22:4n-6) levels were obtained at 150, 900, and 1200 mg/100 g diet in myelin, sciatic nerve, and brain, respectively. Minimal levels were difficult to determine. In all fractions examined accumulation of docosapentaenoic acid (22:5n-6) was the mos...Continue Reading

References

May 1, 1976·The American Journal of Clinical Nutrition·W F Cuthbertson
Jan 1, 1988·Annual Review of Nutrition·M NeuringerW E Connor
Jul 1, 1987·Metabolism: Clinical and Experimental·E N Siguel, M Maclure
Mar 15, 1974·Biochemical and Biophysical Research Communications·J Bernsohn, F J Spitz
Feb 1, 1968·The Journal of Nutrition·C PudelkewiczR T Holman
Jan 1, 1984·Progress in Lipid Research·R R Brenner
Sep 1, 1981·Medical Hypotheses·D F Horrobin
Mar 1, 1982·The American Journal of Clinical Nutrition·R T HolmanT F Hatch

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Citations

Nov 3, 1993·Biochimica Et Biophysica Acta·J W DeWille, S J Farmer
Nov 1, 1992·The International Journal of Biochemistry·J Z ByczkowskiA P Kulkarni
Jan 1, 1991·Progress in Lipid Research·S M Innis
Jan 1, 1994·Progress in Lipid Research·J G Coniglio
Nov 12, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Miki IgarashiStanley I Rapoport
Dec 7, 2000·Chemistry and Physics of Lipids·H S HansenG Petersen
Oct 16, 2003·Progress in Lipid Research·Stephen C Cunnane
Dec 25, 2002·Neurobiology of Aging·S FavrelièreG Durand
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K A YoudimJ A Joseph
Jan 19, 2013·The British Journal of Nutrition·Beth A MacIntoshJ Douglas Mann
Jun 18, 2002·Journal of Neurochemistry·Adriana Ximenes da SilvaMonique Lavialle
Aug 31, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W D Lassek, S J C Gaulin
Sep 11, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Christopher E RamsdenJ Douglas Mann
Jun 13, 2012·Journal of Chemical Neuroanatomy·Priscila Pereira PassosBelmira Lara da Silveira Andrade-da-Costa
Oct 4, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S C Cunnane, P Guesnet
Sep 2, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P GuesnetS C Cunnane
Dec 29, 2015·Current Opinion in Lipidology·Shoug M AlashmaliRichard P Bazinet
Jul 1, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Martine F LuxwoldaFrits A J Muskiet
Nov 29, 2011·Journal of Neurochemistry·Miki IgarashiStanley I Rapoport
Sep 16, 2008·Brain Research·Sheila M Innis
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·P E Wainwright
Jul 21, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kathleen M GuraCarine Lenders

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