Dietary linoleic acid requirements in the presence of α-linolenic acid are lower than the historical 2 % of energy intake value, study in rats

The British Journal of Nutrition
Benjamin ChoqueP Legrand

Abstract

Previous studies on rats and human subjects have established that the linoleic acid (LA) requirement is 2 % of the total energy intake (en%), but is obtained in the absence of α-linolenic acid (ALA) and consequently appear to be overestimated. This raises questions since a recent study including ALA has suggested to divide the historical value by four. However, this recent study has remained inconclusive because the animals used were not totally LA-deficient animals. For the first time, the present study was especially designed using physiological and biochemical markers and performed in two steps: (1) to achieve a specific n-6 fatty acid deficiency model using growing male rats fed either a 0 en% from LA/0 en% from ALA (0LA/0ALA), 0LA/0·5ALA or 2LA/0·5ALA diet, born from female rats fed a 0LA/0·5ALA diet; and (2) to refine the required level of LA in the presence of ALA using rats fed either a 0LA/0ALA, 0·5LA/0·5ALA, 1LA/0·5ALA, 1·5LA/0·5ALA diet, born from female rats fed a 0LA/0·5ALA diet. The first step shows that the best LA deficiency model was obtained using rats fed the 0LA/0ALA diet, born from female rats fed the 0LA/0·5ALA diet. The second step demonstrates that in growing rats, LA deficiency was corrected with an int...Continue Reading

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Citations

Jun 29, 2016·Prostaglandins & Other Lipid Mediators·Shaan S NaughtonAndrew J McAinch
Aug 24, 2017·Science Signaling·Christopher E RamsdenMichael J Iadarola
Jan 25, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Gianfranca CartaRoberto Stancampiano
Apr 4, 2021·International Journal of Molecular Sciences·Nirajan ShresthaDeanne H Hryciw
Apr 17, 2021·The British Journal of Nutrition·Nirajan ShresthaDeanne H Hryciw
Jul 16, 2021·Advances in Nutrition·Susan E CarlsonBeverly Muhlhausler

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