Dietary lipid intake influences the level of cholesterol bound to haemoglobin in human erythrocytes.

European Journal of Nutrition
Milan NikolicVesna Niketic

Abstract

Blood cholesterol levels are affected by diet and in particular by the type of fat intake. We originally showed that a significant but variable amount of cholesterol is firmly bound to haemoglobin (Hb) yielding the Hb-lipid adduct (Hb-Ch) in erythrocytes isolated from normo-lipidemic males. To establish whether dietary lipids affect the level of Hb-Ch in human erythrocytes. Seventy-four healthy free-living adults were separated according to their serum cholesterol levels into two groups: normo-cholesterolemic (LDL cholesterol <3.4 mmol/l and total cholesterol <5.2 mmol/l) (NC) and hyper-cholesterolemic (LDL cholesterol >or=3.4 mmol/l) (HC). Habitual dietary information was used to classify subjects in both study groups into sub-groups of low-fat (<or=30% total energy as fat) and high-fat consumers (>30% total energy as fat). The NC low-fat consumers were placed on a high-lipid (high-fat and high-cholesterol) diet whereas the HC subjects with high-fat intake were assigned to a low-lipid (low-fat and low-cholesterol) diet. Both types of dietary intervention were allowed to continue for 6 weeks. The main variable under scrutiny was the Hb-Ch concentration. In both study groups low-fat intake subjects had low levels of Hb-Ch (appro...Continue Reading

References

Jun 1, 1992·The American Journal of Clinical Nutrition·P N Hopkins
May 1, 1989·The American Journal of Clinical Nutrition·D KromhoutM Pekkarinen
Dec 1, 1986·American Journal of Epidemiology·A KeysM H Keys
Apr 12, 1985·JAMA : the Journal of the American Medical Association
Mar 1, 1995·The American Journal of Clinical Nutrition·E J SchaeferJ M Ordovas
Dec 1, 1994·The American Journal of Clinical Nutrition·M B KatanR P Mensink
Jun 16, 1999·European Journal of Clinical Nutrition·D R ShaharE Kristal-Boneh
Sep 8, 2005·World Review of Nutrition and Dietetics·Mirjana PavlovićArne Oshaug
Nov 10, 2005·Public Health Nutrition·Ingrid H E Rutishauser

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Citations

Dec 8, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cedo MiljevicMihajlo B Spasic
Mar 22, 2012·Natural Product Research·Nagwa E AwadMarwa M Elbatanony

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