Dietary lipid modification of myocardial eicosanoids following ischemia and reperfusion in the rat

Lipids
M Y Abeywardena, J S Charnock

Abstract

Several different edible oils were compared for their ability to modify eicosanoid biosynthesis following experimentally-induced myocardial ischemia and reperfusion in the rat. Two types of palm oil [neutralized, bleached, and deodorized (NBDPO) and refined, bleached, and deodorized (RBDPO)] and partially hydrogenated soybean oil (SBO) were tested against a diet supplemented with sunflower seed oil (SSO) rich in n-6 polyunsaturated fatty acids (PUFA). Fish oil (FO) rich in n-3 PUFA, with its known cardioprotective actions, served as an internal reference point for the study. Test oils were fed as a 12% (w/w) supplement for nine months before the induction of myocardial ischemia and reperfusion. Palm oil diets exerted effects indistinguishable from the SBO group against cardiac arrhythmia, which occurred following alterations to coronary blood flow. Arrhythmic potentials, as expressed by a hierarchical scale (0-9) of arrhythmia score, were: SSO, 1.5 +/- 0.5; FO, 0.9 +/- 0.4; SBO, 3.1 +/- 0.5*; NBDPO, 3.2 +/- 0.5*; RBDPO, 3.3 +/- 0.6*; *P < 0.05 vs. SSO. Following ischemia and reperfusion, both SSO and RBDPO groups tended to show an increase in myocardial prostacyclin, with the effect being more prominent in the RBDPO group (SSO,...Continue Reading

References

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Citations

Oct 25, 2000·The Journal of Nutritional Biochemistry·W R LeifertE J McMurchie
Aug 23, 2001·The Journal of Nutritional Biochemistry·W R. LeifertE J. McMurchie
Nov 13, 2004·The Journal of Nutritional Biochemistry·W R LeifertE J McMurchie
Jul 9, 2011·The British Journal of Nutrition·Ravigadevi SambanthamurthiMohd Basri Wahid
Nov 10, 2011·The British Journal of Nutrition·Peter L McLennanDaniel Raederstorff
Sep 21, 2010·Nutrition Research Reviews·D BesterJ van Rooyen
Jan 25, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A J EsterhuyseJ van Rooyen
Aug 14, 2019·The British Journal of Nutrition·Afroza FerdouseHarold M Aukema
Sep 8, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Y Abeywardena, R J Head

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