Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice

Acta Neuropsychiatrica
Bettina Pyndt JørgensenDorte Bratbo Sørensen

Abstract

Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour. We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis. We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box. Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.

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Citations

Apr 29, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Alan C LoganSusan L Prescott
Oct 11, 2017·Journal of the Science of Food and Agriculture·Katarzyna Skrypnik, Joanna Suliburska
Sep 26, 2020·Nutrients·Arantxa García-LegorretaBerenice Palacios-González
Jun 28, 2020·Neuroscience Bulletin·Sophie OuabbouMing Tsuang
Jan 28, 2021·Nutrients·Gabriele PiuriRoberta Cazzola
Nov 5, 2020·Molecular Psychiatry·Wolfgang MarxFelice N Jacka
Dec 29, 2020·Frontiers in Neuroscience·Janine Aly, Olivia Engmann
Mar 12, 2021·Advances in Nutrition·Kirsten BerdingJohn F Cryan
Nov 23, 2020·Seminars in Cell & Developmental Biology·Jeanette A MaierAndré Mazur
Jul 3, 2021·International Journal of Molecular Sciences·Viktor Bielik, Martin Kolisek
Jul 3, 2021·Journal of Clinical Medicine·Jiezhong Chen, Luis Vitetta

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