Dietary magnesium intake and the incidence of depression: A 20-year follow-up study

Journal of Affective Disorders
Teymoor YaryAnu Ruusunen

Abstract

Depression is a major global public health concern. The aetiology of depression is partly unclear; however, intake of nutrients, such as magnesium, have been suggested to affect depressive symptoms and modify depression risk. This research is a part of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) Study, conducted on a sample of 2320 Eastern Finnish men aged 42-61 years old at the baseline. Magnesium intake was assessed by a 4-day food record. Hospital discharge diagnosis of unipolar depressive disorder was used as an outcome variable. Participants in the middle tertile of dietary magnesium intake had a statistically significantly decreased risk of getting a hospital discharge diagnosis of depression compared to participants in the lowest tertile of magnesium intake (HR 0.49, CI 0.25-0.95, P=0.035) in the prospective setting after multivariable adjustments. In addition, an inverse association between magnesium intake and the risk of depression was found when the combined middle and highest tertiles of magnesium intake were compared with the lowest tertile (HR 0.53, CI 0.29-0.95, P=0.033). Our findings may not be generalizable to individuals below middle-age or women. Moreover, we were unable to consider cases with mild d...Continue Reading

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Citations

Aug 1, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Małgorzata KiełczykowskaJoanna Kocot
Nov 4, 2016·The Australian and New Zealand Journal of Psychiatry·Bingrong LiDongfeng Zhang
Jun 14, 2018·BJPsych Open·Danny PhelanMarc Molendijk
Sep 27, 2018·Current Pharmaceutical Biotechnology·María J F FernándezLaura Rincon-Frutos
Mar 7, 2020·International Journal of Environmental Research and Public Health·Tina LjungbergConnie Lethin
Oct 9, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Jackson CurrieAllison R Webel
Mar 14, 2020·European Journal of Nutrition·Javad Anjom-ShoaePeyman Adibi
Jan 4, 2021·Journal of Affective Disorders·Song Lin, Yang Shen
Dec 29, 2020·Frontiers in Neuroscience·Janine Aly, Olivia Engmann
Jun 1, 2021·American Journal of Obstetrics & Gynecology MFM·Emily S MillerLynn M Yee

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