Dietary management of labrador retrievers with subclinical hepatic copper accumulation

Journal of Veterinary Internal Medicine
H FietenJ Rothuizen

Abstract

Genetic and environmental factors, including dietary copper intake, contribute to the pathogenesis of copper-associated hepatitis in Labrador retrievers. Clinical disease is preceded by a subclinical phase in which copper accumulates in the liver. To investigate the effect of a low-copper, high-zinc diet on hepatic copper concentration in Labrador retrievers with increased hepatic copper concentrations. Twenty-eight clinically healthy, client-owned Labrador retrievers with a mean hepatic copper concentration of 919 ± 477 mg/kg dry weight liver (dwl) that were related to dogs previously diagnosed with clinical copper-associated hepatitis. Clinical trial in which dogs were fed a diet containing 1.3 ± 0.3 mg copper/Mcal and 64.3 ± 5.9 mg zinc/Mcal. Hepatic copper concentrations were determined in liver biopsy samples approximately every 6 months. Logistic regression was performed to investigate effects of sex, age, initial hepatic copper concentration and pedigree on the ability to normalize hepatic copper concentrations. In responders (15/28 dogs), hepatic copper concentrations decreased from a mean of 710 ± 216 mg/kg dwl copper to 343 ± 70 mg/kg dwl hepatic copper after a median of 7.1 months (range, 5.5-21.4 months). Dogs from ...Continue Reading

References

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Sep 25, 2012·Journal of Veterinary Internal Medicine·H FietenJ Rothuizen
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Aug 27, 2013·Journal of the American Veterinary Medical Association·Jason W GagnéRaymond P Glahn
Jan 21, 2014·The Veterinary Journal·Hille FietenJan Rothuizen

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Citations

Feb 11, 2016·International Journal of Molecular Sciences·Xiaoyan WuHille Fieten
Mar 8, 2019·Journal of Veterinary Internal Medicine·Cynthia R L WebsterPenny J Watson
Mar 19, 2019·Journal of Veterinary Internal Medicine·Daniel K LangloisRebecca C Smedley
Jun 30, 2019·Journal of Veterinary Internal Medicine·Xiaoyan WuHille Fieten
Feb 5, 2021·Journal of the American Veterinary Medical Association·Sharon A CenterCynthia R L Webster
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Ronald Jan Corbee, Louis C Penning

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Methods Mentioned

BETA
biopsies
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