Dietary methionine restriction: Effects on glucose tolerance, lipid content and micro-RNA composition in the muscle of rainbow trout

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Mary LatimerPeggy Biga

Abstract

Lean muscle mass plays an important role in overall health, as altered skeletal muscle metabolism can impact both the incidence and prevention of conditions related to metabolic health. Intriguingly, dietary methionine restriction (MR) has been shown to ameliorate this phenotype over time potentially through mechanisms related to changes in myogenic precursor cell (MPC) differentiation status. Recently the role of micro-RNAs (miRs) in regulating the expression of muscle specific transcription factors myoD and myogenin as well as signaling molecules involved in skeletal muscle differentiation has been reported in vitro. We performed an 8week feeding trial to determine if MR in vivo could alter miR abundance as well as change metabolic markers. Results show changes in muscle miR abundance for miR-133a at 4weeks with no significant difference seen in miR-210 or miR-206. After 8weeks of MR feeding fish demonstrated increased clearance of glucose, increased fat accumulation in the liver, and decreased fat accumulation in the muscle. These data demonstrate conservation of MR effects on fish metabolism, and suggest, for the first time, that miR-133a might play a role in tissue response to MR.

References

Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D GarinA Fréminet
Jan 1, 1981·Cell and Tissue Research·I A Johnston, T W Moon
Dec 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J P RichieJ A Zimmerman
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
May 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Prakash K RaoHarvey F Lodish
Aug 23, 2006·The Journal of Cell Biology·Hak Kyun KimAnindya Dutta
Jan 30, 2008·Journal of Lipid Research·Mary E RinellaRichard M Green
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
Aug 6, 2009·Acta Pharmacologica Sinica·Carlos Fabián Flores-JassoLuis Vaca
Dec 14, 2011·The Journal of Experimental Biology·A Cláudia Figueiredo-SilvaSergio Polakof
Jul 17, 2014·Nature Reviews. Molecular Cell Biology·Minju Ha, V Narry Kim
Jun 4, 2017·The Journal of Experimental Biology·Mary LatimerJean-Charles Gabillard

❮ Previous
Next ❯

Citations

May 22, 2018·Frontiers in Endocrinology·Mary Neslund LatimerPeggy R Biga
Jan 6, 2021·Animals : an Open Access Journal From MDPI·Prasanthi KogantiBeth M Cleveland
Oct 27, 2021·Ageing Research Reviews·Umashanker NavikKulbhushan Tikoo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.