Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics

Animal Nutrition
Kelsy RobinsonGuolong Zhang

Abstract

Traditionally, antibiotics are included in animal feed at subtherapeutic levels for growth promotion and disease prevention. However, recent links between in-feed antibiotics and a rise in antibiotic-resistant pathogens have led to a ban of all antibiotics in livestock production by the European Union in January 2006 and a removal of medically important antibiotics in animal feeds in the United States in January 2017. An urgent need arises for antibiotic alternatives capable of maintaining animal health and productivity without triggering antimicrobial resistance. Host defense peptides (HDP) are a critical component of the animal innate immune system with direct antimicrobial and immunomodulatory activities. While in-feed supplementation of recombinant or synthetic HDP appears to be effective in maintaining animal performance and alleviating clinical symptoms in the context of disease, dietary modulation of the synthesis of endogenous host defense peptides has emerged as a cost-effective, antibiotic-alternative approach to disease control and prevention. Several different classes of small-molecule compounds have been found capable of promoting HDP synthesis. Among the most efficacious compounds are butyrate and vitamin D. Moreo...Continue Reading

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Citations

Jun 18, 2019·Advances in Nutrition·Jianmin WuXi Ma
Jul 28, 2019·Animals : an Open Access Journal From MDPI·Long ZhangWenke Bai
Mar 9, 2019·Frontiers in Veterinary Science·Xia XiongYanhong Liu
Apr 24, 2019·Journal of Immunology Research·Shuai WangShiyan Qiao
May 1, 2021·International Journal of Molecular Sciences·Giuseppe MurdacaSebastiano Gangemi

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Methods Mentioned

BETA
histone acetylation
acetylation
histone acetylase
immunoprecipitation

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