PMID: 11934435Apr 6, 2002Paper

Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats

Mutation Research
Richard F BrandaJanice A Nicklas

Abstract

Mitochondrial DNA (mtDNA) is particularly susceptible to mutation by alkylating agents, and mitochondrial damage may contribute to the efficacy and toxicity of these agents. We found that folate supplementation decreased the frequency of the "common deletion" (4.8kb, bases 8103-12,936) in liver from untreated rats and from animals treated with cyclophosphamide but not 5-fluorouracil (5-FU). The relative abundance of mitochondrial DNA was greater after chemotherapy but there was no effect of diet. Rats fed with a purified diet had fewer mitochondrial deletions than those maintained on a cereal-based diet after chemotherapy. These results indicate that diet can modulate the extent of mitochondrial damage after cancer chemotherapy, and that folic acid supplementation may be protective against mitochondrial DNA deletions.

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Citations

Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Golo KronenbergMatthias Endres
Jun 29, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Zhusong MeiLingjia Qian
Jun 25, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tarek M K MotawiAyat Refaat
Mar 18, 2010·The Journal of Nutritional Biochemistry·Wenjiang J FuGuoyao Wu
Apr 29, 2014·Anais Da Academia Brasileira De Ciências·Raquel G SiqueiraCarlos E V DE Almeida
Nov 6, 2018·The Journal of Biological Chemistry·Judith R AlonzoPatrick J Stover
Dec 16, 2010·The British Journal of Nutrition·Ling HeLi Jia
Jun 8, 2017·Genes & Nutrition·Catia Daniela CantarellaSabrina Tosi
Jan 1, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ivonne OlmedoGina Sánchez

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