PMID: 11925466Apr 2, 2002Paper

Dietary mono- and polyunsaturated fatty acids similarly affect LDL size in healthy men and women

The Journal of Nutrition
M KratzU Wahrburg

Abstract

The goal of this study was to investigate the effect of the dietary fat composition on LDL peak particle diameter. Therefore, we measured LDL size by gradient gel electrophoresis in 56 (30 men, 26 women) healthy participants in a controlled dietary study. First, all participants received a baseline diet rich in saturated fat for 2 wk; they were then randomly assigned to one of three dietary treatments, which contained refined olive oil [rich in monounsaturated fatty acids (MUFA), n = 18], rapeseed oil [rich in MUFA and (n-3)-polyunsaturated fatty acids (PUFA), n = 18], or sunflower oil [rich in (n-6)-PUFA, n = 20] as the principal source of fat for 4 wk. Repeated-measures ANOVA revealed a small, but significant reduction in LDL size during the oil diet phase (-0.36 nm, P = 0.012), which did not differ significantly among the three groups (P = 0.384). Furthermore, affiliation with one of the three diet groups did not contribute significantly to the observed variation in LDL size (P = 0.690). In conclusion, our data indicate that dietary unsaturated fat similarly reduces LDL size relative to saturated fat. However, the small magnitude of this reduction also suggests that the composition of dietary fat is not a major factor affect...Continue Reading

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Citations

Aug 26, 2003·The American Journal of Clinical Nutrition·Jean-François MaugerBenoît Lamarche
Oct 7, 2004·The Journal of Nutrition·Juan Antonio MorenoJosé López-Miranda
Sep 13, 2005·The American Journal of Clinical Nutrition·Myriam A Thijssen, Ronald P Mensink
Jan 22, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Aug 12, 2008·Journal of the American College of Nutrition·Arrigo F G CiceroUNKNOWN EUROLIVE Study Group
Jun 17, 2011·Journal of the American College of Nutrition·Annie Bouchard-MercierMarie-Claude Vohl
Jan 13, 2006·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Astrid Lang, Erika Sivarajan Froelicher
Oct 16, 2004·Current Atherosclerosis Reports·Sophie Desroches, Benoît Lamarche
May 24, 2006·Expert Review of Cardiovascular Therapy·Rodolfo PaolettiAndrea Cignarella
Sep 21, 2007·Molecular Nutrition & Food Research·Montserrat FitóMaría-Isabel Covas
Jun 9, 2007·The American Journal of Clinical Nutrition·Marie-Pierre St-OngeDavid B Allison
Aug 8, 2018·Current Nutrition Reports·Victoria M Gershuni
Nov 18, 2006·Clinics in Laboratory Medicine·G Russell WarnickCleland C Landolt
Aug 12, 2008·Domestic Animal Endocrinology·E JordanM Hoenig

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