Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner

Biochemical and Biophysical Research Communications
Akiho NakataniIkuo Kimura

Abstract

The 8-globulin-rich mung bean protein (MPI) suppresses hepatic lipogenesis in rodent models and reduces fasting plasma glucose and insulin levels in obese adults. However, its effects on mitigating high fat diet (HFD)-induced obesity and the mechanism underlying these effects remain to be elucidated. Herein, we examined the metabolic phenotype, intestinal bile acid (BA) pool, and gut microbiota of conventionally raised (CONV-R) male C57BL/6 mice and germ-free (GF) mice that were randomized to receive either regular HFD or HFD containing mung bean protein isolate (MPI) instead of the dairy protein present in regular HFD. MPI intake significantly reduced HFD-induced weight gain and adipose tissue accumulation, and attenuated hepatic steatosis. Enhancement in the secretion of intestinal glucagon-like peptide-1 (GLP-1) and an enlarged cecal and fecal BA pool of dramatically elevated secondary/primary BA ratio were observed in mice that had consumed MPI. These effects were abolished in GF mice, indicating that the effects were dependent upon the presence of the microbiota. As revealed by 16S rRNA gene sequence analysis, MPI intake also elicited dramatic changes in the gut microbiome, such as an expansion of taxa belonging to the phy...Continue Reading

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Citations

Jul 18, 2019·Genes·Antonio PaoliFabio Piccini
Sep 13, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mingxi LiLiya Li
Dec 31, 2020·Microorganisms·Agnieszka ZawadaIwona Krela-Kaźmierczak
Mar 7, 2020·Journal of Agricultural and Food Chemistry·Lingxiao GongJing Wang
Dec 3, 2020·Journal of Agricultural and Food Chemistry·Zhen-Dong YaoGang Zhao

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