Dietary n-3 polyunsaturated fatty acids increase oxidative stress in rats with intracerebral hemorrhagic stroke

Nutrition Research
Yongsoon ParkMyoungsook Lee

Abstract

Intake of n-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has been suggested to associate with an increased risk of hemorrhagic stroke. The present study was designed to investigate the hypothesis that EPA and DHA increase oxidative stress and hemorrhage volume in rats with intracerebral hemorrhagic (ICH) stroke. Thirty-five-week-old male rats were fed an American Institute of Nutrition-93M diet containing 0% (n = 27), 0.5% (n = 15), or 1% EPA + DHA of total energy for 5 weeks. Of 5 rats fed 1% EPA + DHA (41%), 5 died because of excessive bleeding within 12 hours after ICH surgery. Behavior test score and hemorrhage volume were significantly (P < .05) greater in the 1% EPA + DHA-fed rats than in other rats. Magnetic resonance imaging consistently showed that edema and bleeding were visible in only the rats fed 1% EPA + DHA. Levels of superoxide dismutase and glutathione were significantly (P < .05) lower in rats fed 0.5% and 1% EPA + DHA than those fed 0% EPA + DHA. Thiobarbituric acid-reactive substance content was significantly (P < .05) higher in 1% EPA + DHA-fed rats than in 0% and 0.5% EPA + DHA-fed rats. The level of 8-hydroxydeoxyguanosine was significantly (P < .05) hig...Continue Reading

References

Jan 1, 1987·Free Radical Biology & Medicine·C V Smith, R E Anderson
May 1, 1994·Stroke; a Journal of Cerebral Circulation·L H SekhonN C Weber
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·R U KothariJ Khoury
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J AronowskiJ C Grotta
Jun 1, 2000·Journal of Neurotrauma·S W HoffmanE F Ellis
Feb 15, 2001·JAMA : the Journal of the American Medical Association·H IsoW C Willett
Dec 19, 2002·Neurosurgery Clinics of North America·Guohua XiJulian T Hoff
Dec 27, 2002·JAMA : the Journal of the American Medical Association·Ka HeAlberto Ascherio
Jun 23, 2004·Preventive Medicine·William S Harris, Clemens Von Schacky
Mar 23, 2005·Brain Research·Takehiro NakamuraGuohua Xi

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Citations

Sep 1, 2015·Neurochemistry International·Kusumika GharamiSumantra Das
Feb 11, 2015·Leukemia Research·Artur JurczyszynAleksander B Skotnicki
Jul 20, 2016·Oxidative Medicine and Cellular Longevity·Jiyuan BuGang Chen
Nov 25, 2018·Lipids in Health and Disease·Zhi-Zhen QinLi-Qiang Qin
May 12, 2018·BioMed Research International·Lingyu YangJianqiao Zhong

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