Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies.

BMC Sports Science, Medicine and Rehabilitation
Oliver M ShannonTom Clifford

Abstract

Dietary inorganic nitrate (NO3-) is a polyatomic ion, which is present in large quantities in green leafy vegetables and beetroot, and has attracted considerable attention in recent years as a potential health-promoting dietary compound. Numerous small, well-controlled laboratory studies have reported beneficial health effects of inorganic NO3- consumption on blood pressure, endothelial function, cerebrovascular blood flow, cognitive function, and exercise performance. Translating the findings from small laboratory studies into 'real-world' applications requires careful consideration. This article provides a brief overview of the existing empirical evidence basis for the purported health-promoting effects of dietary NO3- consumption. Key areas for future research are then proposed to evaluate whether promising findings observed in small animal and human laboratory studies can effectively translate into clinically relevant improvements in population health. These proposals include: 1) conducting large-scale, longer duration trials with hard clinical endpoints (e.g. cardiovascular disease incidence); 2) exploring the feasibility and acceptability of different strategies to facilitate a prolonged increase in dietary NO3- intake; 3...Continue Reading

References

Sep 30, 1975·Annals of the New York Academy of Sciences·S S Mirvish
Jul 1, 1991·Journal of Medical Microbiology·R S PercivalP D Marsh
Mar 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C F HansonW O Thompson
Dec 1, 1985·Journal of Applied Physiology·P A Tesch, J Karlsson
May 1, 1984·The American Journal of Sports Medicine·P D Gollnick, H Matoba
Apr 7, 1994·Nature·N BenjaminH McKenzie
May 11, 1996·BMJ : British Medical Journal·N Black
Sep 30, 1999·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H S KhoY K Kim
Dec 11, 2002·Journal of Clinical Periodontology·Leif JanssonLars Frithiof
Jun 30, 2004·Free Radical Biology & Medicine·Jon O Lundberg, Mirco Govoni
Sep 28, 2004·The American Journal of Clinical Nutrition·Luisa TesoriereMaria A Livrea
Oct 2, 2004·European Journal of Oral Sciences·J J DoelR P Allaker
Oct 9, 2004·Environmental Health Perspectives·Lorna Fewtrell
Feb 8, 2005·European Journal of Oral Sciences·Justin Johnston DoelRobert Patrick Allaker
Feb 22, 2005·Molecular Aspects of Medicine·Khalid M Naseem
Dec 7, 2005·Archives of General Psychiatry·Georg KemmlerW Wolfgang Fleischhacker
Dec 29, 2006·The New England Journal of Medicine·Filip J LarsenEddie Weitzberg
Jun 1, 2007·Journal of the American Society of Nephrology : JASN·Eric N Taylor, Gary C Curhan
Jan 3, 2008·Nature Reviews. Drug Discovery·Jon O LundbergMark T Gladwin
Sep 17, 2008·Nitric Oxide : Biology and Chemistry·Mirco GovoniJon O Lundberg
Sep 24, 2008·Journal of Dental Research·M T Ashby
May 15, 2009·The American Journal of Clinical Nutrition·Norman G HordNathan S Bryan
May 22, 2009·The American Journal of Clinical Nutrition·Martijn B Katan
May 15, 2010·Journal of Applied Physiology·Stephen J BaileyAndrew M Jones
Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anni VanhataloAndrew M Jones
Aug 21, 2010·BMJ : British Medical Journal·Patrice CarterMelanie J Davies
Oct 19, 2010·Nitric Oxide : Biology and Chemistry·Tennille D PresleyGary D Miller
Nov 13, 2010·Journal of Applied Physiology·Katherine E LansleyAndrew M Jones
Feb 3, 2011·Cell Metabolism·Filip J LarsenEddie Weitzberg
Apr 8, 2011·Medicine and Science in Sports and Exercise·Katherine E LansleyAndrew M Jones
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Ana I Jiménez-MoralesFrancisco Pérez-Jiménez
Jan 18, 2012·International Journal of Sport Nutrition and Exercise Metabolism·Naomi M CermakLuc J C van Loon
Mar 13, 2012·Free Radical Biology & Medicine·Christian HeissTienush Rassaf
Apr 25, 2012·European Journal of Applied Physiology·Daryl P WilkersonAndrew M Jones
Jun 13, 2012·The Journal of Physiology·Andrés HernándezHåkan Westerblad
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lizheng QinSonglin Wang
Aug 10, 2012·Medicine and Science in Sports and Exercise·Oliver PeacockOyvind Sandbakk
Nov 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James KellyAndrew M Jones

❮ Previous
Next ❯

Citations

Aug 24, 2021·The British Journal of Nutrition·Alex GriffithsOliver Michael Shannon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.