PMID: 3749035Oct 1, 1986Paper

Dietary nordihydroguaiaretic acid increases the life span of the mosquito

Proceedings of the Society for Experimental Biology and Medicine
J P RichieC A Lang

Abstract

Our previous findings indicated that a major characteristic of aging organisms is a decrease in reducing capacity. Our objectives were to correct this impairment by administration of nordihydroguaiaretic acid (NDGA), a potent reducing agent, and to determine the effect on adult longevity of the mosquito. NDGA supplements were included in the axenic larval medium or adult diet of mosquitoes of different ages. The mean adult life spans of both sexes increased 42-64% over controls (P less than 0.025), and the most effective doses were 0.001% for females and 0.005% for males. This NDGA effect was dependent on the age when feeding was initiated, since only biosynthetically active larvae and young adults were responsive. Also the effect was not due to dietary restriction. These results confirm the life span-enhancement effect of NDGA using defined conditions and establish the importance of redox status in the aging process.

Citations

Dec 16, 2009·Malaria Journal·Mark Q BenedictAlan S Robinson
Dec 16, 2009·Malaria Journal·Michelle E H HelinskiBart G J Knols
Apr 10, 2014·Parasites & Vectors·Juliana Oliveira Abreu NarcisoMarise Maleck
Jun 21, 2007·Aging Cell·Richard A MillerRandy Strong
Aug 11, 2004·Toxicon : Official Journal of the International Society on Toxinology·E S Garcia, P Azambuja
Apr 23, 2016·Journal of the American Mosquito Control Association·Hamisu A MaimusaJunaid Rahim
Apr 5, 2013·PLoS Computational Biology·Hermann B FrieboesVittorio Cristini
Apr 15, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna LeonovVladimir I Titorenko
Sep 24, 2013·Natural Product Reports·Aikaterini ArgyropoulouAlexios-Leandros Skaltsounis
Oct 12, 2019·Npj Aging and Mechanisms of Disease·Tugsan TezilEric Verdin
Jun 2, 2017·Natural Products and Bioprospecting·Ai-Jun DingHuai-Rong Luo
Aug 31, 2017·Journal of the American Mosquito Control Association·Siriporn PhasomkusolsilSilas A Davidson
May 20, 2021·Malaria Journal·Ajeet Kumar MohantyRapatbhorn Patrapuvich

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