PMID: 11925456Apr 2, 2002Paper

Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats

The Journal of Nutrition
María José PérezA Gil

Abstract

Dietary nucleotides reportedly promote functionality and repair in fibrotic liver. Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, which lead to the impairment of the hepatic function. The aim of this work was to evaluate the influence of dietary nucleotides on liver fibrosis induced by thioacetamide and to elucidate the mechanism by which nucleotides exert their protective effects. Rats consumed ad libitum 300 mg/L thioacetamide in drinking water and were pair-fed diets with (group TN) or without nucleotides (group TS) for 4 mo. Liver histology and extracellular matrix components, liver collagenase and prolyl 4-hydroxylase activities, and tissue inhibitor of metalloproteinases-1 were assessed. The degree of fibrosis was lower in group TN than in group TS. Group TN had lower hepatic concentration of hydroxyproline (P < 0.05), collagen type I (P = 0.12) and type III (P = 0.20), fibronectin (P = 0.05), laminin (P = 0.11) and desmin (P = 0.07), higher collagenolytic activity (P < 0.05), lower prolyl 4-hydroxylase activity (P < 0.05) and lower prolyl 4-hydroxylase (P = 0.10) and tissue inhibitor of metalloproteinase-1 (P = 0.06) expression than group TS. Moreover, expression of tissu...Continue Reading

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Citations

Jul 7, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Yong LinZhong-Bing Zhang
Jun 3, 2004·The Journal of Nutrition·María José Sáez-LaraLuis Fontana
Oct 7, 2004·The Journal of Nutrition·María José PérezAntonio Suárez
Oct 9, 2007·The British Journal of Nutrition·Jose María VieitesAntonio Suárez
Jun 1, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Wei-Lun WongVikineswary Sabaratnam
Jul 22, 2009·Phytotherapy Research : PTR·Yueh-Wern WuWen-Chuan Lin
Dec 3, 2013·Canadian Journal of Physiology and Pharmacology·Eman SaidElsayed M Ammar
Feb 6, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A ArnaudJ M López-Pedrosa

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