PMID: 16615178Apr 15, 2006Paper

Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion

Nutrition
Elisabeth HolenRoland Jonsson

Abstract

The immune system is dependent on purines and pyrimidines as building blocks for DNA and RNA synthesis to enable rapid cell proliferation and protein synthesis. Emerging evidence suggests that dietary nucleotides optimize immune function. We investigated whether growth and function of human immune cells were affected by an exogenous source of nucleotides during specific antigen challenge. Peripheral blood mononuclear cells from healthy individuals (n = 10) were stimulated with influenza virus antigen and either DNA sodium from fish soft roe (DNA), RNA from bakers yeast (Saccharomyces cerevisiae) (RNA), 2' deoxyadenosine 5'-monophosphate sodium (dAMP), 2' deoxycytidine 5'-monophosphate sodium (dCMP), 2' deoxyguanosine 5'-monophosphate sodium (dGMP), 2' deoxyuridine 5'-monophosphate sodium (dUMP) or thymidine sodium (TMP). Growth effects were ascertained by measuring the amount of tritium-labeled thymidine, incorporated into cell DNA. Cell function was measured by detection of IFN-gamma, TNF-alpha and IL-10 production. Specific nucleotide derivatives alone did not affect the growth of healthy peripheral blood mononuclear cells. However, the nucleotide derivatives influenced immune cell growth and cytokine secretion when coculture...Continue Reading

References

Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·A D KulkarniC T Van Buren
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·W C FanslowF B Rudolph
Jun 15, 1983·The Biochemical Journal·M S Ardawi, E A Newsholme
Jun 1, 1997·Current Opinion in Neurobiology·R A North, E A Barnard
Feb 17, 1998·European Journal of Immunology·G B LipfordH Wagner
Jun 6, 2000·Advanced Drug Delivery Reviews·P V Balimane, P J Sinko
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P C Calder
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N SudoC Kubo
Jun 14, 2001·International Journal for Parasitology·D Derouich-GuergourH Pelloux
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Jul 2, 2004·Nature Reviews. Immunology·Richard J Ulevitch

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Citations

Jul 2, 2008·Journal of Materials Science. Materials in Medicine·XuanRi ShenMasanobu Munekata
Sep 9, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Suzie Daniells, Gil Hardy
Feb 3, 2007·Current Opinion in Gastroenterology·Norma A MethenyRay E Clouse
Mar 26, 2011·Topics in Companion Animal Medicine·Ebenezer Satyaraj

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