Dietary oleoyl-estrone delays the growth rate of young rats

European Journal of Nutrition
V TangM Alemany

Abstract

Oleoyl-estrone administration induces the rapid loss of fat preserving body protein. We intended to check whether the fat-shedding effect of oleoyl-estrone arrests growth in young rats, limiting the buildup of protein and fat. Oleoyl-estrone diluted in a powdered hyperlipidic diet (33 mumol/kg) was given for 30 days to 30-day old Zucker lean (Fa/?) rats. Their body weight and food consumption were followed daily; on day 30 of treatment (60-day old rats), whole body composition (lipid, protein) was determined, and plasma energy parameters and leptin were measured. Oleoyl-estrone-treated rats grew more slowly than controls fed the hyperlipidic diet alone, and on day 60 their lipid content was about half that of controls. Protein content per kg was identical in both groups, but treated rats tended to accumulate less nitrogen and energy because of their smaller size. No changes in plasma glucose, urea, triacylglycerols or total cholesterol were observed, but oleoyl-estrone-treated rats showed lower circulating leptin than controls. Despite limiting the accumulation of lipids, oleoyl-estrone slowed, but did not arrest growth of young rats, nor elicit a loss of fat or protein.

Citations

Feb 17, 2005·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Jamil RehmanWayne C Waltzer
Aug 6, 2005·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Koji ShiraishiYoriaki Kamiryo
Dec 22, 2007·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Lutfi TuncIbrahim Bozkirli
Aug 26, 2004·Journal of Dairy Science·B García-PeláezM Alemany
Mar 27, 2010·Obesity·Sabine StrassburgDiego Perez-Tilve
Feb 3, 2011·Medicinal Research Reviews·Xavier RemesarMarià Alemany
Feb 12, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Ruth VilàMarià Alemany

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