Dietary omega-3 fatty acids and susceptibility to ventricular fibrillation: lack of protection and a proarrhythmic effect.

Circulation. Arrhythmia and Electrophysiology
G E BillmanP J Schwartz

Abstract

Recent clinical studies that evaluated the effects of supplemental omega-3 polyunsaturated fatty acids (n-3 PUFAs) on sudden cardiac death have yielded conflicting results. Our aim was to clarify this issue using an established and clinical relevant canine model of sudden cardiac death. Susceptibility to ventricular fibrillation (VF) was evaluated using a 2-minute left circumflex artery occlusion during the last minute of an exercise test in 76 dogs (from 2 independent studies) with healed myocardial infarctions (MI); 44 developed VF (susceptible, VF+), whereas 32 did not (resistant, VF-). These dogs were then randomly assigned to either placebo (1 g/d, corn oil; 15 VF+, 11 VF-) or n-3 PUFA (1-4 g/d, docosahexaenoic acid+eicosapentaenoic acid ethyl esters, 29 VF+, 21 VF-) groups. Seven sham (no-MI) dogs were also treated with n-3 PUFA (4 g/d). After treatment (3 months), the exercise+ischemia test was repeated. Dietary n-3 PUFAs produced significant (P<0.01) increases in red blood cell and left ventricular n-3 PUFA levels. Nine post-MI (5 placebo versus 4 n-3 PUFA) and 2 sham dogs died suddenly during the 3-month treatment period. The n-3 PUFA treatment failed to prevent arrhythmias in VF+ dogs (decreased in 27% placebo versus ...Continue Reading

References

Jun 1, 1992·American Heart Journal·P L McLennanJ S Charnock
May 9, 1985·The New England Journal of Medicine·D KromhoutC de Lezenne Coulander
Nov 1, 1995·JAMA : the Journal of the American Medical Association·D S SiscovickL H Kushi
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·G E BillmanA Leaf
Apr 16, 1998·The American Journal of Cardiology·P J Schwartz
Apr 12, 2002·The New England Journal of Medicine·Christine M AlbertJing Ma
Feb 7, 2003·European Journal of Clinical Nutrition·M L BurrP C Elwood
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Penny M Kris-EthertonUNKNOWN AHA Nutrition Committee. American Heart Association
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Oct 21, 2004·The Cochrane Database of Systematic Reviews·L HooperS B J Ebrahim
May 19, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefan DheinFriedrich-Wilhelm Mohr
Nov 4, 2005·Circulation·Alexander LeafUNKNOWN Fatty Acid Antiarrhythmia Trial Investigators
Jul 25, 2006·Cardiovascular Research·Hester M Den RuijterRuben Coronel
Apr 3, 2007·Lancet·Mitsuhiro YokoyamaUNKNOWN Japan EPA lipid intervention study (JELIS) Investigators
Jan 16, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David J A JenkinsStephen C Cunnane
Jun 3, 2008·American Heart Journal·Matthias WilhelmWerner Guenther Daniel
Sep 5, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Arun SridharCynthia A Carnes
Dec 25, 2008·BMJ : British Medical Journal·Hernando LeónRoss T Tsuyuki
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·George E Billman
Jun 8, 2010·BMC Cardiovascular Disorders·Kristian B FilionJames M Brophy
Oct 12, 2010·The New England Journal of Medicine·Daan KromhoutUNKNOWN Alpha Omega Trial Group
Jun 24, 2011·The New England Journal of Medicine·Raffaele De Caterina

❮ Previous
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Citations

Feb 28, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Clemens von Schacky
Sep 7, 2012·Cardiology Research and Practice·Andrew Ramadeen, Paul Dorian
Jun 21, 2012·Circulation. Arrhythmia and Electrophysiology·Christine M Albert
Mar 13, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·David R Van Wagoner
Jun 18, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Clemens von Schacky
Oct 31, 2017·Nutrients·Narcis TribulovaJan Slezak
Dec 1, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Thomas A RixErik B Schmidt
Nov 20, 2016·Journal of Muscle Research and Cell Motility·Jérôme Roy, Jean-Yves Le Guennec
Oct 25, 2020·Current Problems in Cardiology·Addis AsfawRami N Khouzam
Apr 13, 2021·Journal of the American Heart Association·Thomas A ZelnikerMichelle L O'Donoghue

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