PMID: 9164986May 1, 1997Paper

Dietary oxidized linoleic acid modifies lipid composition of rat liver microsomes and increases their fluidity

The Journal of Nutrition
E HochgrafU Cogan

Abstract

The effect of dietary oxidized oil on the lipid composition, fluidity and function of rat liver microsomes was studied. Male growing rats were fed diets containing 10 g/100 g of a fresh (control) or oxidized (experimental) linoleic acid-rich preparation for 4 wk. High levels of fluorescent compounds and of thiobarbituric acid reactive substances indicated the occurrence of substantial lipid peroxidation in the microsomes of the experimental rats. The fluidity of the liver microsomes derived from rats fed the experimental diet was significantly higher than that of the membranes of the controls. This was due to profound differences in lipid composition of the liver microsomes, namely, a lower cholesterol to phospholipid molar ratio and a greater arachidonic acid content in the phospholipids of the rats fed the experimental diet. The fluidity differences were accompanied by greater activity of the microsomal enzymes, aldehyde dehydrogenase and NADPH cytochrome C reductase. The study demonstrated that ingestion of oxidized lipids caused profound alterations in membrane composition, fluidity and function. These alterations are likely to be associated with an enhanced cholesterol turnover, as indicated by the greater cholesterol excr...Continue Reading

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Citations

Oct 26, 1999·Neurourology and Urodynamics·M A HassR M Levin
Mar 13, 2014·Journal of the Science of Food and Agriculture·Aziouz AidoudAna B Rodriguez
Mar 24, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Sunny O AbarikwuChigozie L Onuah
Mar 21, 1998·Current Opinion in Lipidology·J P Poisson
Aug 18, 2005·Phytotherapy Research : PTR·K ArunaVenugopal P Menon
Nov 18, 2000·Biochimica Et Biophysica Acta·S Nigam, T Schewe
Aug 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H SuzukiJ H Rhim
Apr 1, 2000·The Journal of Nutritional Biochemistry·E HochgrafS Mokady
Oct 12, 2005·The Journal of Nutritional Biochemistry·Bettina König, Klaus Eder
Jun 12, 2014·The Journal of Physical Chemistry. B·Sampada BagaiTian Tang
Mar 1, 2012·Lipids in Health and Disease·Juliane VaradyRobert Ringseis

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